Protein Alignment CG14857 and Slc22a3

DIOPT Version :10

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: NP_035525.1
• Gene: Slc22a3 / 20519
• MGIID: 1333817
• Length: 551
• Species: Mus musculus
• Alignment Length: 580
• Identity: 150/580 - (25%)
• Similarity: 245/580 - (42%)
• Gaps: 82/580 - (14%)

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQ-HWC---YHEALENR---SFE 60
            |||.|.|.|..||:|..:.|||.....|....:.....:|..|. :||   ...||..|   |.|
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPE 68

  Fly    61 EIAAIYAP-----------------------FGKEASC---TRLDKIEGDRVTVSNETCQRWIYN 99
            |...:..|                       ...|.||   |.........|:.|.:      :.
Mouse    69 EEWNLTTPELHVPAERRGQGHCHRYLLEATNTSSELSCDPLTAFPNRSAPLVSCSGD------WR 127

  Fly   100 YDFGFRSMNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVG-- 162
            |.....::.::.:.||::|:...:.|::..||.|.|.||.|...||.||:  :|....|..||
Mouse   128 YVETHSTIVSQFDLVCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRL--IIYLISCFGVGIT 190

  Fly   163 DFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPW 227
            ..:..:|.|...|.|||.:.|:.....:...|::|.|.:..|.|.: :...:.:.|.||.::.|.
Mouse   191 GVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRI-VGIVIQMFFTLGIIILPG 254

  Fly   228 LSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNG-------M 285
            ::....:|:......:|...:..|:|:||.||.:|||||...|.|:..|:.:|..||       .
Mouse   255 IAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYS 319

  Fly   286 EVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVE 350
            |:...|.|....:|:                ||:|||.:||.:|:::|.:..:::.:..:...:.
Mouse   320 EITVTDEEVSNPSCL----------------DLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLG 368

  Fly   351 GMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVT 415
            .:|.:.::.|.:..:|..|...:..|...|:||:.....:.:..| :|| |..|...||..   .
Mouse   369 LIGGNLYIDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAG-VSC-LVTAFLPEGIP---W 428

  Fly   416 LLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAA-- 478
            |....|...||||:|.:.:.....|||.||.:|:.|::...........::|:|:.   :|||
Mouse   429 LRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLF---RLAAIW 490

  Fly   479 --APSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVS 536
              .|.:|..:|.....|..::||||....||.|:.|.|..|..:   ...|.|:....||
Mouse   491 LELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQ---LHQCGRKKKTQVS 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	137/543 (25%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	137/543 (25%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O75751	284..288		2/3 (67%)