DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	578	Identity:	149/578 - (25%)
Similarity:	238/578 - (41%)	Gaps:	73/578 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAI 65
            |.|.:||::.||.|.:|||.:.||.........|...|......|.|.|  ....|.|.|.....
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHC--RPPPNASLEPWVLP 63

  Fly    66 YAPFGKEASCTRLDKIEGDRVTVSNET------C-QRWIYNYDFGFRSMNAELNWVCNDAYKARI 123
            ..|.||...|.|.  :.....::.|:|      | ..||||....  ::..|.:.||.......:
Mouse    64 LGPNGKPEKCLRF--VHLPNASLPNDTQGATEPCLDGWIYNSTRD--TIVTEWDLVCGSNKLKEM 124

  Fly   124 GQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATA 188
            .||:|..|.|:|...||.|.||.||...:..:............::.:|..:.|||.:.|.:.:.
Mouse   125 AQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISG 189

  Fly   189 NYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFY 253
            ......||.:|::....|.:: |.|:|.|:.:|..:.|.|:.....||       .|||.|:..:
Mouse   190 ISLSTIILNVEWVPTSTRAIS-STTIGYCYTIGQFILPGLAYAVPQWR-------WLQLSVSAAF 246

  Fly   254 FV-------VQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQ 311
            |:       |.||.:||:.......|:..|:.:|.|||.:      |...:..:.:.|.:.|.:.
Mouse   247 FIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNGKK------EEGEKLTVEELKFNLQKDI 305

  Fly   312 TA-----GIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSG 371
            |:     |:.||.|...||:|:..:...:..|..::.:::..||..|::.:::..:|..|..|:.
Mouse   306 TSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAK 370

  Fly   372 FIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTS 436
            ||..|..|.:||:.|....::..|:...|| :.:|:| .|...|.|..|......|...|..:
Mouse   371 FITILSISYLGRRITQGFLLILAGVAILAL-IFVSSE-MQLLRTALAVFGKGCLSGSFSCLFL-- 431

  Fly   437 QFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPET 501
             :.|||.||.:|..|:...::.|...|.::|.:...|......|::|...:.|........|.||
Mouse   432 -YTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTLLGGSAAFFLLET 495

  Fly   502 NNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLHQLNGQTKSETEAE 559
            .||.||.|:.|            ...|                 :|...:||.|.|||
Mouse   496 LNRPLPETIED------------IQDW-----------------YQQTKKTKQEPEAE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	135/516 (26%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	92/355 (26%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	135/516 (26%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		6/12 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950