DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and F45E10.2

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001022174.1	Gene:	F45E10.2 / 185801	WormBaseID:	WBGene00009729	Length:	538	Species:	Caenorhabditis elegans

Alignment Length:	522	Identity:	128/522 - (24%)
Similarity:	236/522 - (45%)	Gaps:	67/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DQILEKCGSAGRYQYLMILLLGY-IAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAIYA 67
            :.|.|..||.||:|.:..:|:.. ||| .::|..|          |.:              :.:
Worm    69 ESIFEGLGSFGRFQQIQFILICIPIAF-VSMHVMS----------WTF--------------VVS 108

  Fly    68 PFGK---EASCTRLDKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFF 129
            |..|   |.:.||:|..|    .::.....||         .|:.:..|:     :|.: |:::|
Worm   109 PARKICNETNETRIDGCE----ELAYSASDRW---------EMDGDNGWI-----RATV-QAVYF 154

  Fly   130 LGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMF 194
            :|.::|:||.||:.|:|||.:.:........|...|...|.....:||.:..:|......|.:..
Worm   155 IGQMIGSFTCGVMADKIGRKKVLFWCLVLQVVCALLLIVAPTWWIYAILKAGTGFTQPGIYGVAV 219

  Fly   195 ILVLEYLAPKLRNM--AISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQ 257
            :|.:|.:..|.|:.  .|:...|:   :|.::...::....::|:.....|:..|:...:|:::.
Worm   220 VLGIELVGKKYRSFIAVIANVFGV---IGGVLLAVMAYFIVDYRLLHASIAIPSLIFITYYWMIH 281

  Fly   258 ESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTP 322
            |||:||:::...:.|...|...|::|...:.....|...:...|   .:.:.:.:.|:|||:|||
Worm   282 ESARWLVSQEKYDDANVVLCATANWNKKTIPKNWAEKIEKKMDV---TATKKKDSFGVFDLIRTP 343

  Fly   323 NLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATA 387
            .:||.::.....:.:|::.:..::...:..|.|.||.|....::..|:..|..||..|:||:...
Worm   344 QMRKRTIANFVMWPVTTMMYYGLTMRSDVGGGSLFVTFVTSQLMELPAVIIVALLIDRLGRRIMY 408

  Fly   388 FLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGI 452
            ..|:...|:|..|..:......:|..|.:|:.    .:..:|:.|||...:.|||.||.:|:..:
Worm   409 SGAIFTAGMLLLASWLTHDLIPSQYAVIMLMV----AKGAVSVAYTVMYTYTSELFPTVIRNTAV 469

  Fly   453 AA----VHLAAAGASFVSPYLI-HLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLAD 512
            ..    ....|..|||::.:|: ..|..:...|..||||.....|  ..|||||.|:|||.::::
Worm   470 GCCSTIARFGAISASFIAFFLVDRFGRIVMIIPFTILALCASIVS--WTMLPETVNQQLPDSISE 532

  Fly   513 GE 514
            .|
Worm   533 VE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	125/508 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	83/349 (24%)
F45E10.2	NP_001022174.1	MFS_SLC22	121..518	CDD:340875	100/427 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010