DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_032792.2	Gene:	Slc22a6 / 18399	MGIID:	892001	Length:	545	Species:	Mus musculus

Alignment Length:	535	Identity:	133/535 - (24%)
Similarity:	240/535 - (44%)	Gaps:	30/535 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAI 65
            |.|:.:|::.|..||:|.:.:.::.........|...||....:|.|.|...|..|.|.:.....
Mouse     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPAHHCRPPANANLSKDGGLEA 65

  Fly    66 YAPF---GKEASCTRL----DKIEGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARI 123
            :.|.   |:..||.|.    :..|.:...|:......|:|:......::..|.|.||:.....::
Mouse    66 WLPLDKQGRPESCLRFPFPHNGTEANGTGVTEPCLDGWVYDNSTFPSTIVTEWNLVCSHRAFRQL 130

  Fly   124 GQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATA 188
            .||||.:|.|:|...||.|.||:||.:.:||......|......||.|...:.|||.:||::..:
Mouse   131 AQSLFMVGVLLGAMMFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCIFRLLSGMSLAS 195

  Fly   189 NYYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALF 252
            .......|.:|::  .:...|..||| |..:.||..:...::....:||       .|||.|::.
Mouse   196 IAINCMTLNMEWM--PIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWR-------HLQLAVSVP 251

  Fly   253 YFVV-------QESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPE 310
            :||.       .|||:|..:...::..:..|:.:|..||.:.:.|..........::::|:....
Mouse   252 FFVAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLQTSLQKELTLNKG 316

  Fly   311 QTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQG 375
            | |...:|||.|.||::.|.:...:..||.::..:..:::|.|:|.:::..:|..|..|:.|:..
Mouse   317 Q-ASAMELLRCPTLRRLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCF 380

  Fly   376 LLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFAS 440
            |:.:.:||:.....::|..|:  |.|...:...|   :..:..:.|:..:..::..:.....:..
Mouse   381 LVINSMGRRPAQLASLLLAGI--CILVNGIIPRG---HTIIRTSLAVLGKGCLASSFNCIFLYTG 440

  Fly   441 ELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQ 505
            ||.||.:|..|:......|...|.|||.:........:.|..|...:.:.||..|.:||||..:.
Mouse   441 ELYPTMIRQTGLGMGSTMARVGSIVSPLISMTAEFYPSIPLFIFGAVPVAASAVTALLPETLGQP 505

  Fly   506 LPITLADGEAFGKGE 520
            ||.|:.|.::..:|:
Mouse   506 LPDTVQDLKSRSRGK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	127/512 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	89/351 (25%)
Slc22a6	NP_032792.2	2A0119	11..509	CDD:273328	127/512 (25%)
		MFS	129..499	CDD:119392	95/384 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..545		1/6 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950