DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and C06H5.6

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_507509.3	Gene:	C06H5.6 / 180170	WormBaseID:	WBGene00007394	Length:	556	Species:	Caenorhabditis elegans

Alignment Length:	575	Identity:	139/575 - (24%)
Similarity:	246/575 - (42%)	Gaps:	87/575 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVH-YYSQN--IIGFVPQHWCY------HEALEN 56
            :|.|::|...|..||||     :|.|: .||:|| .::.|  |:.|:.:...:      .|::::
Worm    25 LDADKVLTAFGKYGRYQ-----MLAYV-ITTSVHMLFALNMMIMPFITKSVEFLCDLPDPESIDS 83

  Fly    57 RSFEEIAAIYAPFGKEASC----TRLDKIEGDRVTVSNETCQRWIYNYDFGFRS-MNAELNWVCN 116
            ..|..:..        .||    |:|: |..|.:.|:..:     |||....:| :.::.:.||.
Worm    84 AHFSPLVG--------DSCHLQDTQLN-ITIDCLAVNGAS-----YNYLADKKSTITSDFDLVCE 134

  Fly   117 DAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCI 181
            ....|....|:|.:|.::.:.....|.|.:||....::........:.:...|.|.:.|.:||.|
Worm   135 YQGMAEHATSIFLVGGMIVSPFVSQLSDILGRRPLFLIPLYISVAANLICAAAPNYLIFLLFRFI 199

  Fly   182 SGLAATANYYLMFILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQ 246
            ||:|.|:.....|:|.:|.::.:.|:: |.....|.:..|.::|....|...|||:....:::..
Worm   200 SGVATTSFSMTGFVLCMESVSLEFRSL-IPVLTTISWVGGYMLAGVFYVFFKNWRVLYFAASVPG 263

  Fly   247 LVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQ 311
            |:...|::...||..||:|:.|.......:.....||...:...|       |...:.:.|.|..
Worm   264 LLTIPFFWFTPESLHWLMTKQNDRKIKKYINESVAFNKQTISLID-------CRNIQTVDNAPAT 321

  Fly   312 T-AGIFDLLRTPNLRKVSL-LVVFTFMLTSLS--------FNTISRNVEGMGLSPFVVFSLFAVV 366
            | ...|..|..|   |:.: :|:.:|:|..:|        ::|.....|..|      :.|..:|
Worm   322 TKTRTFRALFYP---KIFVHVVINSFILIVMSGTYWALSLYSTELSEDETTG------YFLSGLV 377

  Fly   367 VPPSGFIQGLLQSRVGRKATAFLA-------MLCTGLLSCALGVALSTEGAQKNVTLLLAFALPM 424
            ..|:||:...|.....||..:|.:       ||||        |.:..:|..|.:..|||
Worm   378 ELPAGFLSVFLLIAFKRKTVSFYSLAFTAVFMLCT--------VYIPMQGNYKMIFPLLA----- 429

  Fly   425 RLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLL 489
            :...|:.:.......||..||.:|:.....|.......|..:||:..|......||:::::::.:
Worm   430 KSTNSIVWASQPLLYSEATPTTIRNVFSGVVSFVGELGSIGAPYMNRLTAINQDAPAILISIMSI 494

  Fly   490 TASGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVR 544
            .|:...|:.|||.|::||   .|.:.|..|.   .|..|::..|..:.||:|||:
Worm   495 VAAFLVLLQPETKNKKLP---EDLDQFDAGP---LFRGWKKQKDLEASEASEEVK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	125/528 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	84/360 (23%)
C06H5.6	NP_507509.3	MFS_SLC22	115..504	CDD:340875	96/418 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010