DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14857 and F17C11.12

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_505789.1	Gene:	F17C11.12 / 179514	WormBaseID:	WBGene00008923	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	564	Identity:	124/564 - (21%)
Similarity:	220/564 - (39%)	Gaps:	123/564 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QILEKCGSAGRYQYLMILLLGYIAFTTTVH--------YYSQNIIGFVPQHWCYHEALENRSFEE 61
            |||||..:...|              .|||        .||..:..||      ..|:.::....
Worm    17 QILEKTNTGTMY--------------NTVHSDDLLKMGRYSILLCIFV------EVAMLSQLSNT 61

  Fly    62 IAAIY---APFGKEASCTRLDKIEGDRVTVSN-ETCQRWIY-------NYDFGFRSMNAELNWVC 115
            :..:|   ||..|  ||       |:....|| |.|..:.|       .::..|..:..:...:|
Worm    62 MLMVYAGAAPTIK--SC-------GNMTFSSNEEACLHYSYCKEQKEMTFERQFYGITEQFKLLC 117

  Fly   116 NDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRC 180
            .||...::|.|:..||.::|...||.:||:.||...::......|:...::..:::..:|.|||.
Worm   118 EDAKLEKLGTSIQMLGVMLGCVVFGQIGDQYGRKTPMMFCLCMCFIFGIMSALSADFKKFTIFRT 182

  Fly   181 I-----SGLAATANYYLM---------FILVLEYLAPKLRNMAISGTLGICFCLGALVAPW--LS 229
            |     .|.:..:..|::         :|..|...:|   |:.:.|.|...|      ..|  |:
Worm   183 ILCFFNGGQSTISVVYMIENIPKRTRGYISTLISYSP---NVILLGILAFFF------QQWDRLA 238

  Fly   230 VLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGM----EVKAA 290
            ::..    :||..|::.|.      .:.||.:||:.:..:..|......|..|:|:    .:...
Worm   239 LVIS----FLTVPAIIMLA------FLHESPRWLMQKGQISHAKKVFLAIEKFDGVPAAKSLNET 293

  Fly   291 DFEAFRRNCIVKRKLSNQPE--QTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMG 353
            :.|.|..|...|:......|  :....:.|.:|..:...:.::.|||..|:|...:|..|:..:.
Worm   294 ELENFLENEHDKQVADGNTEVGKQHSFWHLFKTKEIMTGTFVIAFTFFATTLINYSIMFNLGAVA 358

  Fly   354 LSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLL 418
            .|.::...|..::........|||.    .|...|...:|.|:.|.   |.:|.      :..::
Worm   359 GSIYMNSILIGLLRYSFSLFSGLLD----YKFEKFDRKMCHGICSV---VTISI------IVAII 410

  Fly   419 AFALP---------MRLGISMCYTVTSQ-------FASELLPTCVRSRGIAAVHLAAAGASFVSP 467
            ||.|.         :|:|:.:...:|||       .::||:||.:||...:...|.:......:|
Worm   411 AFCLTDTTATFSVLIRIGVLLSCAMTSQAIIVASIASNELMPTAIRSISYSTAQLCSRFGIVFAP 475

  Fly   468 YLIHL----GTKLAAAP-SLILALLLLTASGCTLMLPETNNRQL 506
            ::.||    |......| :::||:.|........::|||.|:.|
Worm   476 HVFHLNLYTGIDFPVLPYAILLAIGLADFIFFRFLIPETKNKPL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	119/558 (21%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	81/381 (21%)
F17C11.12	NP_505789.1	2A0119	<109..521	CDD:273328	97/443 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010