DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and K05F1.6

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	NP_001342018.1	Gene:	K05F1.6 / 173977	WormBaseID:	WBGene00019408	Length:	858	Species:	Caenorhabditis elegans

Alignment Length:	588	Identity:	131/588 - (22%)
Similarity:	228/588 - (38%)	Gaps:	96/588 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQ---YLMILL--LGYIAFTTTVHY------YSQNIIGF-------VPQH 47
            :||:.||...|....:|   |::|.|  :.:..|...|.|      :...:.||       :..|
Worm   200 IDFEGILNIIGGCRWWQIWIYVLIALQQIPHAMFNLNVVYMMYDPEFQCMVPGFNDTNDTTISSH 264

  Fly    48 WCYHEALENRSFEEIAAIYAPFGKEA-----SCTRLDKIEGDRV---------TVSNET------ 92
            ..|...:::  .:.|:.::.....:.     ||...::.| :|.         |..:|.
Worm   265 GPYLWGVDD--IKNISFVFPNANSDGAYQRDSCYFYERSE-ERYRQLRRMPLETAMSEAWKDVAP 326

  Fly    93 ---CQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLFF-LGSLMGTFTFGVLGDRIGRVRAV- 152
               ||.:.:..|....::..:.|.|| |::.|:....:|: :|.|:|....|:..|:|||...:
Worm   327 KKKCQAYHFEKDVMVETIVTDFNLVC-DSWFAKGHAHMFYSIGYLLGCVLGGIASDKIGRKPTII 390

  Fly   153 ---ILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTL 214
               ||::..|....|...|.    .|.:.|.:|.:...|.....:.|.:|....|.|.| :...|
Worm   391 GFGILSSMLGVFLPFNDYYP----MFLLIRLLSAICNEAADLAAYTLCMEITGTKYRAM-VGSML 450

  Fly   215 GICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHI 279
            ...:.||..:...::.|..:|:.....:|.|..:..:|...:.||.:||:.:..|..|...::..
Worm   451 QAPWALGYALLALIAYLTKSWKTIQVIAAGLHFMSIIFICSIPESPRWLMVQNRVSEAEEVIRKA 515

  Fly   280 AH-----FNGMEVK-----AADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFT 334
            ..     ||.....     .:|.|.....   :|||:.:.....|..||.....||..::.|...
Worm   516 CREPPFPFNMCTTSKCGNLPSDLELVSHR---ERKLNKKNGGKIGFLDLFTMKELRYRTISVCIV 577

  Fly   335 FMLTSLSFNTISRNVEGMGLSPFVVFSLF---------AVVVPPSGFIQGLLQSRVGRKATAFLA 390
            ||.|:|.:..:...:.........:|:.:         |:.:|.......::|  :|||....|.
Worm   578 FMATALVYYGLVMALSDQSAPGRTLFTGYFHLNNGIAGAIEIPTLFACVWMMQ--LGRKKALMLT 640

  Fly   391 MLCTGL------LSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRS 449
            ::.:||      ||...|          :..|.|||....::.:...:.:...|.|||.||.||:
Worm   641 LITSGLFIIVAMLSMVSG----------HYMLALAFMYFGKIAVQGAFNILYIFTSELYPTVVRN 695

  Fly   450 RGIAAVHLAAAGASFVSPYLIHLGT-KLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLADG 513
            ..:....:.|...|.:|.|:..|.. .|...|.:|.|:..|.|.....:||||:.:.||.||.|.
Worm   696 TAVGVTSMVARFGSGLSSYIALLSNISLPIVPMIIFAVFSLFAGMLVFVLPETSEKPLPETLDDA 760

  Fly   514 EAF 516
            ..|
Worm   761 INF 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	123/569 (22%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	83/373 (22%)
K05F1.6	NP_001342018.1	MFS_SLC22	333..746	CDD:340875	96/433 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840