Protein Alignment CG14857 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_650392.1
• Gene: CG14857 / 41791
• FlyBaseID: FBgn0038262
• Length: 560
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 577
• Identity: 144/577 - (24%)
• Similarity: 239/577 - (41%)
• Gaps: 88/577 - (15%)

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENR-------- 57
            |.|.::|:..|..||:|.|..:.|.............:|....||.|.|:...|:|.
Human     1 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILG 65

  Fly    58 --SFEEIAAIYAPFG---KEASCTRLDK-----IEGDRVTVS-----NETC-QRWIYNYDFGFRS 106
              |.|.:.||..|.|   :...|.|..:     ::.:....|     .|.| ..|:|:......:
Human    66 SLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTST 130

  Fly   107 MNAELNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGR--------VRAVILANQCGFVGD 163
            :.|:.|.||:......:.||::..|.|:|....|...||.||        ::..::.....|...
Human   131 IVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPA 195

  Fly   164 FLTTYA--SNLVQFAI---------------FRCISGL-AATANYYLMFILVLEYLAPKLRNMAI 210
            | ..|.  ..|:.||:               :|...|| |.:....|..:.|:|:.|.:.|.:.:
Human   196 F-PVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLAVMEWTAARARPLVM 259

  Fly   211 S-GTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFV-------VQESAQWLITRT 267
            : .:||..|..|...|....|  .:|       .||||||::.:|:       :.|||:||:|..
Human   260 TLNSLGFSFGHGLTAAVAYGV--RDW-------TLLQLVVSVPFFLCFLYSWWLAESARWLLTTG 315

  Fly   268 NVEGAIARLKHIAHFNGMEVKAADFEAFRRNCI---VKRKLS-NQPEQTAGIFDLLRTPNLR--- 325
            .::..:..|..:|..||   |.|..:......:   ::.:|| .||..:.|  .|||.|.||
Human   316 RLDWGLQELWRVAAING---KGAVQDTLTPEVLLSAMREELSMGQPPASLG--TLLRMPGLRFRT 375

  Fly   326 KVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLA 390
            .:|.|..|.|..|   |..::.:::.:|.:.|::.....||..|:.....||.|.:||:.|...:
Human   376 CISTLCWFAFGFT---FFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAAS 437

  Fly   391 MLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAV 455
            :|..||...|..:.....||.::...:|...     |:...:|..:.::|||.||.:|...:...
Human   438 LLLAGLCILANTLVPHEMGALRSALAVLGLG-----GVGAAFTCITIYSSELFPTVLRMTAVGLG 497

  Fly   456 HLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLAD 512
            .:||.|.:.:.|.:..||......|.|:...:.:.:....|:||||.:..||.|:.|
Human   498 QMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQD 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	139/562 (25%)
		MFS	126..470	CDD:119392	97/384 (25%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	139/562 (25%)
		MFS	122..541	CDD:119392	108/441 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153252
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950