DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a8

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	537	Identity:	129/537 - (24%)
Similarity:	244/537 - (45%)	Gaps:	35/537 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWC-------YHEALENRS 58
            |.|.::||:.|..||:|...::||.:.......|...||....:|.|.|       ...:.:...
Frog     1 MSFAELLERTGGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIPDHKCKANDTGYQSNSTDETG 65

  Fly    59 FEEIAAIYAPFGKEASCTRLDKIEGDRVTVSNETCQR------------WIYNYDFGFRSMNAEL 111
            :|.::|.....|:...|....:|:. |:..||.|...            |.|:.|....::..|.
Frog    66 YERLSAPLDANGQPDRCLEYVEIQW-RMVGSNSTWNNSSELATRPCTIGWEYSKDEFSSTIITEW 129

  Fly   112 NWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGF-VGDFLTTYASNLVQF 175
            :.||....:.::.||::..|.|:|....|.|.||.|| ||:::.:.... |......::.|.:.:
Frog   130 DLVCGRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGR-RALLIWSYFQLAVSGVCAAFSPNYLSY 193

  Fly   176 AIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYL 239
            .|||.::|:|.:........|::|::..::|  .::||| |..:..|.|:...|:....:||...
Frog   194 CIFRFLTGMALSGIGLNTTALIVEWVPTRVR--TVTGTLAGFSYTAGQLLLAGLAYGMRDWRWLQ 256

  Fly   240 TCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAHFNGM--EVKAADFEAFRRNCIVK 302
            .|.:|...:..|:.:...|||:||:.....|.|:..::.:|:.||.  |.:....|:.:...|
Frog   257 LCVSLPFFIYFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKKEEGEKITLESLKSEMI-- 319

  Fly   303 RKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVV 367
            ::|:: .:.:..:.||:||..:|::|..:...:..||.::..::.:::...:|.:::..:|..|.
Frog   320 KELAS-AKSSYSVIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVSIYLIQVIFGAVD 383

  Fly   368 PPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCY 432
            .|:..:.......||||.|.|::::..|:...| .:.:..| .|...|.|..|.   :..::..:
Frog   384 FPAKLVSATAMIYVGRKFTQFMSLILGGIAIIA-NIFVPNE-LQTVRTSLAVFG---KGCLAASF 443

  Fly   433 TVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLM 497
            :....:.:||.||.:|..|:......|.....|:|.:..||......|.||.....:.:..|...
Frog   444 SCIFLYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPIISGLCVFF 508

  Fly   498 LPETNNRQLPITLADGE 514
            ||||.|:.||.|:.:.|
Frog   509 LPETVNKPLPDTIEEVE 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	123/520 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	82/347 (24%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	95/415 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100