DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a20p.1

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_004913725.1	Gene:	slc22a20p.1 / 100489586	XenbaseID:	XB-GENE-6463910	Length:	572	Species:	Xenopus tropicalis

Alignment Length:	586	Identity:	159/586 - (27%)
Similarity:	258/586 - (44%)	Gaps:	65/586 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSF---EEI 62
            |.|:.:|...|..||:|.:...:|.........|.:.||....||.|.|:..:|:|.:.   ::.
Frog     1 MGFNDLLLSVGGLGRFQIIHTTMLLIPMLFMGCHNFLQNFSAAVPAHRCWVPSLDNNTMGYDQDH 65

  Fly    63 AAIYAPFG---KEASCTRLDKI-----EGDRVTVSNETCQ-RWIYNYDFGFRSMNAELNWVCNDA 118
            ...:.|..   |..||.|..|.     .....|...|.|: .|:|:......::..|.:.||...
Frog    66 LPAFIPMDESEKPLSCLRYRKALHSMWTNGTSTNHTEPCEDGWVYDKSDFSSTIVTEWDLVCKLR 130

  Fly   119 YKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQ-----CGFVGDFLTTYASNLVQFAIF 178
            ...:|.||::..|.|:|....|.|.||:|| ||:::.:.     ||....||    .|.:.:..|
Frog   131 KMRQIAQSIYMAGVLVGAVLLGGLSDRLGR-RALLIGSNLVMAVCGTCAAFL----PNFITYCTF 190

  Fly   179 RCISGLAATANYYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYLTCS 242
            ||:.|:|.:........|:||:..||.|  .|.||| ...|..|.::...|:.....||
Frog   191 RCLCGIAFSGITLNTNSLILEWTPPKGR--TIMGTLFAAGFTCGQILLAALAYGIREWR------ 247

  Fly   243 ALLQLVV-ALFYF------VVQESAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCI 300
             .||..| |.|||      :|.|||:|||.:.....|:..|:.:|..||   |..:.:......:
Frog   248 -WLQFAVSAPFYFFFLYSWLVPESARWLILKGRSHEALKALQRVAIING---KREEGQKLSEMIL 308

  Fly   301 VKRKLS--NQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLF 363
            :....|  ||.::...:|||.|||.:|||::.::..:..:.::|..:..:::..|:|.|::...|
Frog   309 ISHMQSELNQVKRPHSLFDLFRTPGMRKVTICLMMVWFSSGVAFYGLGMDLQNFGISIFLLQFTF 373

  Fly   364 AVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEG--AQKNVTLLLAFALPMRL 426
            ..:..|:..:..||.:.:||:.|....::.:       ||||.|..  .|....|.:..|:..:.
Frog   374 GAIDMPAKVVAALLMTYMGRRVTQATVLILS-------GVALLTNAFIPQGMKILRMVLAVFGKG 431

  Fly   427 GISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTA 491
            .::..:.....|:.||.||.:|..|:..|.:.|...|.|:|.::.|.......||.|..:..:.|
Frog   432 CMAASFACAYLFSGELFPTVIRQTGMGVVAMMARVGSVVAPLVLLLWEISPILPSAIYGIAAIIA 496

  Fly   492 SGCTLMLPETNNRQLPITLADGEAFGKGESMLSFDCWRRHDDDVSKEATEEVRLHQLNGQTKSET 556
            .|....|.||||:|||.::.:.||..:|:..|            .|...|||.|:|...|..:..
Frog   497 GGAATFLMETNNQQLPESVEEVEARSQGKHTL------------KKVLKEEVPLNQCESQNMAPK 549

  Fly   557 E 557
            |
Frog   550 E 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	144/526 (27%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	100/360 (28%)
slc22a20p.1	XP_004913725.1	MFS	101..485	CDD:391944	110/407 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000