DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a2

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_002933908.1	Gene:	slc22a2 / 100487774	XenbaseID:	XB-GENE-965056	Length:	544	Species:	Xenopus tropicalis

Alignment Length:	563	Identity:	140/563 - (24%)
Similarity:	239/563 - (42%)	Gaps:	88/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFE-EIAAIY 66
            ||::||..|....:|..:.:||.:|:...:..|.....:||||.:.|....:...|.| |....|
Frog     4 FDELLEHIGEFDAFQKQIFILLCFISVVFSPIYVGIVFLGFVPDYRCVSAGIPEPSNECEWTLNY 68

  Fly    67 -APFGKEAS-------------------CTRLDKIEGDRVTVSNETCQ-RWIYNYDFGFRSMNAE 110
             .|.|...|                   ||........::.::|  |: .|.||....  |:..|
Frog    69 TGPNGSTDSLYMSQCYQYDVDWNSTSLNCTNSSLNITSKLPITN--CKDGWDYNTTGS--SLVTE 129

  Fly   111 LNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGR----VRAVILANQCGFVGDFLTTYASN 171
            .|.||.|::|....||...:|..:|....|.:.||.||    :.::::.   |..| .|..:|.|
Frog   130 FNLVCGDSWKLDFFQSCVNIGFFIGGLISGYIADRFGRKPFLISSILIT---GIFG-ILMAFAPN 190

  Fly   172 LVQFAIFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLGI----CFCLGALVAPWLSVLA 232
            ......||.|.|..:...:...:|||.|::..:.|.     |:||    .|.:|.|:...::.:.
Frog   191 YPLVVTFRFIQGFVSKGCWLSGYILVAEFVGLEHRR-----TVGIVYQAAFTVGLLLLSGVAYVL 250

  Fly   233 GNWRIYLTCSALLQLVVAL-------FYFVVQESAQWLITRTNVEGAIARLKHIAHFNG------ 284
            .:||       .||:.|.:       :|:.|.||.:|||::.....|.|.:..||..||
Frog   251 PHWR-------WLQMTVTIPYFFFLAYYWCVPESPRWLISQNRKAEAKAIIHTIAKKNGKMVPDF 308

  Fly   285 MEVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNV 349
            :|...||.||..:             |.....||:|||.:||.:|::::.:...::.:.....::
Frog   309 LESLTADEEAGEK-------------QVPSFLDLVRTPQIRKHTLILMYIWFTCAVVYQGSIMHM 360

  Fly   350 EGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNV 414
            .....:.:..|.:.|:|..||..:..:...||||:....:..:.|| ::|.: .|....|..
Frog   361 GSTAENIYFDFFISALVEFPSAILIIVTVDRVGRRYPWLVCCIITG-ITCLI-TAFIPHGYS--- 420

  Fly   415 TLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAA- 478
            .|::..:...|:||::.|.:.....:||.||.:|:.||............::|::::   :|||
Frog   421 WLIITLSCVSRMGITVSYEMVCLVNAELYPTFIRNLGIMVCSSMCDLGGVITPFIVY---RLAAI 482

  Fly   479 ---APSLILALLLLTASGCTLMLPETNNRQLPITLADGEAFGK 518
               .|.::.|:|...:......||||..|.||.|:.:.|...|
Frog   483 WQELPLIVFAVLATVSGILVYFLPETKGRALPETIEEAENLHK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	133/544 (24%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	87/364 (24%)
slc22a2	XP_002933908.1	2A0119	12..516	CDD:273328	133/544 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000