DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a13a

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_021322911.1	Gene:	slc22a13a / 100007819	ZFINID:	ZDB-GENE-070912-473	Length:	537	Species:	Danio rerio

Alignment Length:	595	Identity:	142/595 - (23%)
Similarity:	241/595 - (40%)	Gaps:	120/595 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILEKCGSAGRYQYLMI-------LLLGYIAFTTTVHYYSQNIIGFVPQHWCYHE----ALE 55
            :|.:|||..|..|.:|.|::       |:|.:...:...::...|       |.|..:    |..
Zfish     3 NFGEILEAIGDFGLFQKLLLFALCFPNLILPFQLSSLVFNHADTN-------HHCNTDWILKADP 60

  Fly    56 NRSFEEIAAIYAPFGKEAS---CTRLDKIEGDRVTV------SNETC-QRWIYNYDFGFRSMNAE 110
            |.:.||...:..|...:.|   |.....::.:...:      ...|| ..|::|......::..:
Zfish    61 NLTKEEQLNLTLPRLSDGSFNPCQMYKPVDWNLSAIQEYGLNQTTTCTDGWVHNDTIYEATIVTD 125

  Fly   111 LNWVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQF 175
            .:.||.:....|..|::||.|.|:|...||...:..||.||..:.                :|..
Zfish   126 FDLVCENVNIFRGAQTVFFAGVLVGAILFGPFSESFGRKRATQIP----------------MVLM 174

  Fly   176 AIFRCISGLAATANYYLMFILVLEYLAPKLRN-MAISGTLGICFCLGALVAPWLSVLAGNW---- 235
            .||..::||  :.|:|:       ||..:..| :.:.|     |.:.::      :||..|
Zfish   175 LIFTVVTGL--SPNFYV-------YLVSQFINGVGLGG-----FRINSI------ILASEWIGVA 219

  Fly   236 -RIYLTC-----SALLQLV-VALFYFV-----------------------VQESAQWLITRTNVE 270
             |.|..|     :||.|:: :|:.|||                       :.|||:||:.|...:
Zfish   220 QRSYAACLSQVLAALGQVMFLAVVYFVRDWRLDQFIMAGPIGIVVIYIWFLPESARWLLDRGRTK 284

  Fly   271 GAIARLKHIAHFNGMEVKAADFEAFRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTF 335
            .|...::..|..|...|..:         :|:..|..:|.:..||..|..:..|||..|.:.|.:
Zfish   285 DAKKLIQKAAAVNKRAVPES---------LVEEVLKEKPVEKGGIKILFGSRVLRKYFLAITFAW 340

  Fly   336 MLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCA 400
            ...:|::.::|.||...||..|:...:|.:...|..|:.......||||.:..::::..|.| |.
Zfish   341 CALNLAYYSLSLNVGKFGLDIFLTQLIFGLSEIPVHFLCMWSLEVVGRKPSLIVSLVLGGCL-CL 404

  Fly   401 LGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFV 465
            |.||:    .|.:...:...|...|..::...:|.:.:..||.||.:|.........||...|.:
Zfish   405 LTVAV----PQNSSIAIAVLATCGRFLMNAAGSVCNVYFQELFPTSIRQTATGLGSTAARAGSML 465

  Fly   466 SPYLIHLGTKLAAAPSLILALLLLTASGCT-LMLPETNNRQLPITL--ADGEAFGKGESMLSFDC 527
            ||.:..|.....:.|.::::.|.| |||.| .:||||...:||.:.  |:|:...|..|..:.||
Zfish   466 SPVVNMLEIFHFSIPMVVISSLAL-ASGVTAFLLPETRRTELPASTEEAEGKRKPKLTSPATRDC 529

  Fly   528 WRRHDDDVSK 537
               .|..|:|
Zfish   530 ---EDTKVTK 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	129/554 (23%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	91/378 (24%)
slc22a13a	XP_021322911.1	Sugar_tr	12..507	CDD:331684	127/552 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950