DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14857 and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	569	Identity:	142/569 - (24%)
Similarity:	254/569 - (44%)	Gaps:	55/569 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIA-FTTTVHYYSQNIIGFVPQHWCYHEAL------ENRS 58
            |.|:.:|.:....||:| .|:|.:.::. |:...|:...|.|..:|.|.|...:|      ||.|
Zfish     1 MRFEDLLSELNGFGRFQ-KMVLCINFLGRFSLGCHFLLGNFIAAIPSHHCNISSLDVDGVFENLS 64

  Fly    59 FEEIAAIYAPF---GKEASCTRLDKIEGDRVTVSNET-------CQR-WIYNYDFGFRSMNAELN 112
            .||...:..|.   |..|||......:...:..|:.:       ||. |.::......::..:.:
Zfish    65 QEERLTVGVPAQEDGTPASCHMFSHPQFQLLINSSSSSDLPVVECQNGWHFDNSTFISTLATQWD 129

  Fly   113 WVCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAI 177
            .||:.....::..::||||.:.|...||.|....||...::::...|......:..:|:||.||:
Zfish   130 LVCDKRALGKLTTTIFFLGVMFGAAAFGSLSAMFGRKPMLLVSYILGMGFGLCSVLSSSLVMFAV 194

  Fly   178 FRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTL-GICFCLGALVAPWLSVLAGNWRIYLTC 241
            .|..||...|.:..:..:|.:|:::.:.|.:.  |.: .:.:..|.:..|.::....:|| :||.
Zfish   195 LRFFSGFTITGSVIISTVLNVEWVSIEHRKLV--GVIDSLAWTFGFMGFPVIAYFIRDWR-WLTV 256

  Fly   242 SALLQLVVALF-YFVVQESAQWLITRTNVEGAIARLKHIAHFNGME-----VKAADFEAFRRNCI 300
            :..|..|:::. ::.|.|||:|||.....:.|...||..|..|..:     :|..|        :
Zfish   257 AISLPNVISIITWWWVPESARWLIVNGKADKAHYYLKKCAAMNHKKEVTARIKPED--------L 313

  Fly   301 VKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFT-FMLTSLSFNTISRNVEGMGLSPFVVFSLFA 364
            .|..::::..:.....||:|||.:|::|||...| |.:.::::. ||.|:.|.||:.::...::.
Zfish   314 SKIIVTDRGSRKYSYLDLVRTPKMRRLSLLTGITWFSVATVAYG-ISFNITGFGLNMYLTQFVYG 377

  Fly   365 VVVPPSGFIQGLLQSRVGRKATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFAL-----PM 424
            .:..|:.|....|..:.||..|...::|..| :|..:.:.:..|   |.|...:...|     ..
Zfish   378 AIEIPAKFCIYYLLDKFGRHVTQAGSLLFVG-ISFIINIFIPKE---KTVIRTVIAVLGKGCSAT 438

  Fly   425 RLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLL 489
            ..|..:.||      |||.||.||..|:......|.....|:|.::......:....:||..|.|
Zfish   439 SFGTVILYT------SELYPTVVRQNGMGYTSFIARFGVSVAPLILLSNDVWSYFSQVILCFLAL 497

  Fly   490 TASGCTLMLPETNNRQLPITLADGEAFGKGES-MLSFDCWRRHDDDVSK 537
            :|:.....||||:.:.||.|:.|.|...|.:: :|..|......|::.|
Zfish   498 SAAFVAYQLPETSGKCLPETIDDIEGIRKDKNGLLLQDRKMEEKDNMEK 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	131/528 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	91/356 (26%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	131/527 (25%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	96/385 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950