DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14857 and slc22a5

DIOPT Version :9

Sequence 1:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	572	Identity:	143/572 - (25%)
Similarity:	249/572 - (43%)	Gaps:	81/572 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAIY 66
            ::|:.....|..|.:...:..||..|..:|.:|......:...|.|.|..:......:.|.:|..
Zfish     3 NYDEDTAFLGQTGPFFIRLFCLLNLIYISTGLHGLYIVFVAASPAHRCRVDVNLTEDWLEASAPT 67

  Fly    67 APFG----KEASCTR-----LDKIEGD-------RVT-VSNETCQ-RWIYNYDFGFRSMNAELNW 113
            ....    :.:.|.|     |..:.|.       .:| :..|.|: .|:|:.|....::.:|.:.
Zfish    68 ETLSNGDLQVSQCWRYSLQTLTNLSGQGYSPGQINITDIPRERCEDGWVYSADVYHSTIVSEWDL 132

  Fly   114 VCNDAYKARIGQSLFFLGSLMGTFTFGVLGDRIGRVRAVI--LANQCGFVGDFLTTYASNLVQFA 176
            ||:..::..:..|..::|.|:|:...|.|.||.||.:.:.  ||.:...:  |..:::.:.:.|.
Zfish   133 VCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLFGSLAAEALLM--FAQSFSPSWLIFC 195

  Fly   177 IFRCISGLAATANYYLMFILVLEYLAPKLRNMAISGTLG--ICFCLGALVAPWLSVLAGNWRIYL 239
            :.....|....:.|...|:|..|.|:..||  .:..|||  :.:|:|.::.||::....:||..|
Zfish   196 VLYFFIGAFQISLYITAFVLGNEVLSGSLR--VLFTTLGAFLHYCVGYMLLPWVAFAIRHWRTLL 258

  Fly   240 TCSALLQLVVALFYFVVQESAQWLITRTNVEGAIARLKHIAH----------FNGMEVKAADFEA 294
            ...:.|.:|....::::.||.:||:::.:|:.:.|.|:..|.          |...::|.|.|:
Zfish   259 RVLSGLTVVYIPLWWLIPESPRWLLSQGHVQESEAILRDAARKNRVPAPEVIFKQSQIKEAAFQ- 322

  Fly   295 FRRNCIVKRKLSNQPEQTAGIFDLLRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVV 359
                   |.|.|        ..|:|||.|:|:.:.:.:..:|..::.:..:|.|...:...||:.
Zfish   323 -------KSKYS--------ALDVLRTSNIRRTTFMCLLLWMAINIGYFGLSLNTTNLSGDPFLN 372

  Fly   360 FSLFAVVVPPSGFIQGLLQSRVGRK--ATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFAL 422
            ..|.||...|:..:...|.....|:  .:||| ::..|.|   |.|.|..:..|   ||.||..:
Zfish   373 CFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFL-VIGGGFL---LLVQLIPDRLQ---TLALALEM 430

  Fly   423 PMRLGISMCYTVTSQFASELLPTCVRSRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALL 487
            ..:.|.:|.:||...:.:||.||.:|:.|:.....||...|..:||:|.|||.....|.:::..|
Zfish   431 AGKFGFTMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYIIFLGTFNRHLPYVLMGSL 495

  Fly   488 LLTASGCTLMLPETNNRQLPITL-----------------ADGEAFGKGESM 522
            .:|||...|.||||..:.||..|                 .||   |.||.|
Zfish   496 TITASLANLFLPETFGKVLPENLEQMQKSRSFPGRDKQSVEDG---GGGEKM 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	135/531 (25%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	94/359 (26%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	134/530 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588439
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950