DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and SLC22A8

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001171661.1	Gene:	SLC22A8 / 9376	HGNCID:	10972	Length:	542	Species:	Homo sapiens

Alignment Length:	546	Identity:	135/546 - (24%)
Similarity:	217/546 - (39%)	Gaps:	63/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            |.|.|||.:.|....:|::.:|:.||.:..::.|...|......|.|.|  ....|.|.......
Human     1 MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHC--RPPHNASTGPWVLP 63

  Fly    68 YAPFKRPS-CTRL-----ASINMDGSNATASSEPC-NRWIYHYDHGFISMNADLNWVCDDAYKAR 125
            ..|..:|. |.|.     ||:..|...|   .||| :.|:|:.....|....||  ||:......
Human    64 MGPNGKPERCLRFVHPPNASLPNDTQRA---MEPCLDGWVYNSTKDSIVTEWDL--VCNSNKLKE 123

  Fly   126 VGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFL----GDSATIFAETLLTFSASRFVSG 186
            :.||:|..|.:.|.|:.|.|.||.||...:.    |.:|    ..|...|:.|...:...||:.|
Human   124 MAQSIFMAGILIGGLVLGDLSDRFGRRPILT----CSYLLLAASGSGAAFSPTFPIYMVFRFLCG 184

  Fly   187 LAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLL 251
            ......:....||.:|:|...||:: ::..:...|..|..........:..||...:..::|..:
Human   185 FGISGITLSTVILNVEWVPTRMRAI-MSTALGYCYTFGQFILPGLAYAIPQWRWLQLTVSIPFFV 248

  Fly   252 VTGFYFL----IQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARS- 311
                :||    ..||.:|||.......|...|||||.||.               |.:|.|..|
Human   249 ----FFLSSWWTPESIRWLVLSGKSSKALKILRRVAVFNG---------------KKEEGERLSL 294

  Fly   312 ---QMSMQKQARLI-------DSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMF 366
               ::::||:..|.       |.|::|.||.....:::.:......|.:::..||...::.:::.
Human   295 EELKLNLQKEISLAKAKYTASDLFRIPMLRRMTFCLSLAWFATGFAYYSLAMGVEEFGVNLYILQ 359

  Fly   367 SLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGIL-LAFWTQHSATVMVCLLLMCR 430
            .:|.....|:.........:.||..|.     |..|:.|...|| |.|......||...|.:..:
Human   360 IIFGGVDVPAKFITILSLSYLGRHTTQ-----AAALLLAGGAILALTFVPLDLQTVRTVLAVFGK 419

  Fly   431 FGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLV 495
            ..:|.:.......::||.||.:|.:|:.|.::.....|.:||.:...........:||..|..|:
Human   420 GCLSSSFSCLFLYTSELYPTVIRQTGMGVSNLWTRVGSMVSPLVKITGEVQPFIPNIIYGITALL 484

  Fly   496 SAWICLLLSETRNKKLPLTLAEGEEF 521
            .....|.|.||.|:.||.|:.:.|.:
Human   485 GGSAALFLPETLNQPLPETIEDLENW 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	128/527 (24%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	91/393 (23%)
SLC22A8	NP_001171661.1	2A0119	11..503	CDD:273328	128/527 (24%)
		MFS	96..493	CDD:119392	99/427 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950