DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	542	Identity:	121/542 - (22%)
Similarity:	234/542 - (43%)	Gaps:	47/542 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            |.|:::|.:.|...|:|.:.:.|..|.:.:::.|...||....:|.|.|......|.|......:
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGLEV 65

  Fly    68 YAPFKR----PSCTRLAS-------INMDGSNATASSEPC-NRWIYHYDHGFISMNADLNW--VC 118
            :.|..|    .||.|..|       :|...:|.|.::||| :.||  ||:..........|  ||
Human    66 WLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWI--YDNSTFPSTIVTEWDLVC 128

  Fly   119 DDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRF 183
            ......::.|||:.||.:.|.::||.|.||:||.|.::|......:..:...||.....:.|.|.
Human   129 SHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRL 193

  Fly   184 VSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCV------FYGLGMICASWQGVWLGSWRSFM 242
            :||:|....|.....|.:|::.       ::...||      .|.||....:.....:..||...
Human   194 LSGMALAGISLNCMTLNVEWMP-------IHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQ 251

  Fly   243 VWTALP--QLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFN--RRDVSEADYELFRQHCK 303
            :..:.|  ...:..::|:  |||:|..:....|.....|:|||:.|  |.:.::...|:.|
Human   252 LLVSAPFFAFFIYSWFFI--ESARWHSSSGRLDLTLRALQRVARINGKREEGAKLSMEVLR---- 310

  Fly   304 TKESEARSQMSMQK-QARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFS 367
               :..:.:::|.| ||..::..:.|.||...:.:::::...:..|..:..:::|..:|.:::..
Human   311 ---ASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQV 372

  Fly   368 LFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFG 432
            :|.....|:.:....|....||:...:.::...|:.....|::    .|..:.|...|.::.:..
Human   373 IFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVI----PQDQSIVRTSLAVLGKGC 433

  Fly   433 ISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSA 497
            ::.:.......:.||.||.:|.:|:.:....|...|.:||.:......:.:....|...:.:.::
Human   434 LAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAAS 498

  Fly   498 WICLLLSETRNKKLPLTLAEGE 519
            .:.:||.||..:.||.|:.:.|
Human   499 AVTVLLPETLGQPLPDTVQDLE 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	116/525 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	77/384 (20%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	116/525 (22%)
		MFS	135..505	CDD:119392	79/389 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153816
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950