DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_445989.2	Gene:	Slc22a7 / 89776	RGDID:	621699	Length:	535	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	131/551 - (23%)
Similarity:	237/551 - (43%)	Gaps:	59/551 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWC---------YHEQ--L 56
            |.|:::|.|.|....:|...|.|..|...::..|:.....:..||.|.|         .|:.  |
  Rat     1 MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWL 65

  Fly    57 ENRSYAEIAAIYAPFKRPSCTRLA------SINMDGSNATASSE--------PCNR-WIYHYDHG 106
            |.....|....::     ||.|.|      ::.: |:..:.|.|        ||:: |  .||..
  Rat    66 EAHLPRETDGSFS-----SCLRFAYPQTVPNVTL-GTEVSNSGEPEGEPLTVPCSQGW--EYDRS 122

  Fly   107 FISMNADLNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSAT 169
            ..|......|  ||......::..:.||:|.:.|.:::|.|.||.||.:.:::|.....:....:
  Rat   123 EFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMS 187

  Fly   170 IFAETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVW 234
            ..:...:.|..:|.::|.|....:.::..|.||::....|:|. .:...||:..|::..:..|..
  Rat   188 AASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVA-GVISTVFWSGGVLLLALVGYL 251

  Fly   235 LGSWRSFMVWTALPQLLVTGFYFL--IQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYEL 297
            :.|||..::...||  .|.|...:  :.|||:||:|:...:.|:..|...||.|.|.|.|.
  Rat   252 IRSWRWLLLAATLP--CVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEG---- 310

  Fly   298 FRQHCKTKESEARSQMSMQKQA----RLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGL 358
                  :...||.:.:...::|    ..:|.|:..:||...:...:|:..|...|..::.:|.||
  Rat   311 ------SLSQEALNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGL 369

  Fly   359 SISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMV 423
            .::.:....||.....||.|....:.:..||:.|. ..|.....:|..|.:|::..|:...|.:|
  Rat   370 GLNVYQTQLLFGAVELPSKIMVYFLVRRLGRRLTE-AGMLLGAALTFGTSLLVSLETKSWITALV 433

  Fly   424 CLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSII 488
              ::...|..:..|.:.: .::||.||.:|.:||.:..:.....:.::|....||..:.....:.
  Rat   434 --VVGKAFSEAAFTTAYL-FTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVA 495

  Fly   489 TCILLLVSAWICLLLSETRNKKLPLTLAEGE 519
            ...:.||:|...|||.||:..:||.|:.:.|
  Rat   496 YGGIALVAACTALLLPETKKAQLPETIQDVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	125/534 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	89/379 (23%)
Slc22a7	NP_445989.2	2A0119	11..521	CDD:273328	125/534 (23%)
Slc22a7	NP_445989.2	MFS	144..511	CDD:119392	90/383 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.960