DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and SLC22A16

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_149116.2	Gene:	SLC22A16 / 85413	HGNCID:	20302	Length:	577	Species:	Homo sapiens

Alignment Length:	570	Identity:	128/570 - (22%)
Similarity:	222/570 - (38%)	Gaps:	94/570 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWC----------YHE----- 54
            |:.|....|...|:|.:|..:..........||.|...:|..|.|.|          :|.
Human     6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWS 70

  Fly    55 ------------------QLENRSYAEIAAIYAPFKRPSCTRLASINMD--GSNATASSE--PCN 97
                              ||:|....|::         .|:|....|..  |...|.|.:  ||.
Human    71 LEDTGALLSSGQKDYVTVQLQNGEIWELS---------RCSRNKRENTSSLGYEYTGSKKEFPCV 126

  Fly    98 RWIYHYDHGFISMNADLNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANC 160
            .. |.||.......|...|  |||..:.|.:.|.||..|.:.|::.||...||:||...:...:.
Human   127 DG-YIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWATSS 190

  Fly   161 CGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLM--FILVLEYV---SPTMRSVGLNLTMCVF 220
            ..||...|..||....||.|:||.  ||..|:.||:  |:.|:|::   |.|..||.|:    .|
Human   191 SMFLFGIAAAFAVDYYTFMAARFF--LAMVASGYLVVGFVYVMEFIGMKSRTWASVHLH----SF 249

  Fly   221 YGLGMICASWQGVWLGSW---RSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRV 282
            :.:|.:..:..|..:.:|   :..:....:|.:|..   :::.|:..||::...::.|:..:..:
Human   250 FAVGTLLVALTGYLVRTWWLYQMILSTVTVPFILCC---WVLPETPFWLLSEGRYEEAQKIVDIM 311

  Fly   283 AKFNRRDVSEADYELFRQHCKTKE----------SEARSQMSMQKQARLIDSFKLPRLRLRLIYV 337
            ||:||           ...||..|          |.:.:::.....:.|..::.:.:   |.:.|
Human   312 AKWNR-----------ASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITK---RTLTV 362

  Fly   338 TVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGL 402
            .:::...:|.:.:.|.|...|..:.::...|..:...|:..|........||:.....|:..:.|
Human   363 WLIWFTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSAL 427

  Fly   403 MTATTGILLAFWTQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAAL 467
               ..|:::....:| ..:.|...::.:|.|....|.....:.||.||.|||..:....:.....
Human   428 ---ACGVVMVIPQKH-YILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLA 488

  Fly   468 SFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAE 517
            |.::||.:.|.:.:.....:....:.|:|..:.|.|.||..|:|..|..|
Human   489 SILAPFSVDLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEE 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	124/557 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	85/391 (22%)
SLC22A16	NP_149116.2	Sugar_tr	14..535	CDD:331684	124/557 (22%)
SLC22A16	NP_149116.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	543..577
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850