DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and Slc22a23

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001028339.1	Gene:	Slc22a23 / 73102	MGIID:	1920352	Length:	689	Species:	Mus musculus

Alignment Length:	659	Identity:	147/659 - (22%)
Similarity:	252/659 - (38%)	Gaps:	165/659 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMDFDEILVKC--GDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWC----YHEQLENR 59
            :.:|:|..::..  |....||..|:.|..:....:....|:.:.:...||.||    ...:|...
Mouse    76 LLLDYDGSVLPFLGGLGGGYQKTLVVLTWIPALFIGFSQFSDSFLLDQPDFWCRGAGKGTELAGA 140

  Fly    60 S----YAEIAAIYAPFKRPSCTRLASINMDGSNATASSEP----------------CNRWIYHYD 104
            :    :.::....:|...|..|  ||.....:.:.:|..|                |:.|.|...
Mouse   141 TVTGRWGDMGNWTSPSATPFST--ASWGTTSNRSNSSDTPPLPSPPGKGNNDSNCDCHAWDYGIR 203

  Fly   105 HGFISMNADLNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDS 167
            .|.| .|....|  |||:.:|..:.:....||.:.|.|:.|.:.|.:|| :.|:|.:....|...
Mouse   204 TGLI-QNVVSKWDLVCDNTWKVHIAKFSLLVGLIFGYLITGCIADWVGR-RPVLLFSTIFILIFG 266

  Fly   168 ATIFAETLLT-FSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFY---------- 221
            .|:.....:| ||..||..|.........::.|.:|...|..|.:   :||...:
Mouse   267 LTVALSVNVTMFSTLRFFEGFCLAGIILTLYALRIELCPPGKRFI---ITMVASFVAMAGQFLMP 328

  Fly   222 GLGMICASWQGVWLGSWRSFMVWTAL---PQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVA 283
            ||..:|..||           |..||   |.||:..::.:..||.:||:..|.|:.|:..:
Mouse   329 GLAALCRDWQ-----------VLQALIICPFLLMLLYWSIFPESLRWLMATQQFESAKKLI---- 378

  Fly   284 KFNRRDVSEADYELFRQHCKTKESEARSQM-SMQKQARLIDSFKLPRLRLRLIYVTVV------F 341
                       ..|.:::|.:.||:.:..| .::|:        |.|...::..|.||      .
Mouse   379 -----------LYLTQKNCVSPESDIKGVMPELEKE--------LSRRPKKVCIVKVVGTRNLWK 424

  Fly   342 SIVTLCYNTM---------SRNVEGLSIS-PFV------MFSLFALTLPPSGIFQTQVQKHFGRK 390
            :||.||.|::         :|::.|..:. |.:      .:::.::.| .|.:....|.|..||:
Mouse   425 NIVVLCVNSLTGYGIHHCFARSMMGHEVKVPLLENFYADYYTMASIAL-ASCLAMCLVVKFLGRR 488

  Fly   391 --------FTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGISVTTGSTMQIS--- 444
                    .|::.|:...||:.     |:..::||..:.   |.|....|:|.:......|:
Mouse   489 GGLLLFMILTALASLLQLGLLN-----LIGKYSQHPDSE---LQLKLAVGMSDSVKDKFSIAFSI 545

  Fly   445 -----------------TELMPTCVRSSGLAVIHVTAAALSFISPFI-LHLDT-YFRAASSIITC 490
                             .|:.||.:|..||.::..:|......:|.| ||... ||........|
Mouse   546 VGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGMLTAPIIELHNQKGYFLHHIIFACC 610

  Fly   491 ILLLVSAWIC-LLLSETRNKKLPLTLAEGEEF--------GKGERMFDFMRSFKK--ADQHDLSA 544
            .|:.:   || |||.|:||:.||..:|.||.:        .|||:......:..|  :..||::|
Mouse   611 TLICI---ICILLLPESRNQNLPENIANGEHYTRQPLLPHKKGEQPLLLTNAELKDYSGLHDVAA 672

  Fly   545 DTIEKLMGD 553
                  :||
Mouse   673 ------VGD 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	133/594 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	97/441 (22%)
Slc22a23	NP_001028339.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		2A0119	98..631	CDD:273328	129/585 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..188		5/27 (19%)
		MFS	230..>359	CDD:119392	35/143 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030