Protein Alignment CG14856 and SLC22A5

DIOPT Version :9

• Sequence 1: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 134/579 - (23%)
• Similarity: 235/579 - (40%)
• Gaps: 103/579 - (17%)

  Fly     4 DFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGF-------VPDHWCYHEQLENRSY 61
            |:||:....|:...:|       .|:.|::|.........|.       .|:|.|......|.|.
Human     3 DYDEVTAFLGEWGPFQ-------RLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSS 60

  Fly    62 A--------------EIAAIYAPFKRPSCT--RLASI----------NMDGSNATASSEPC-NRW 99
            |              |:.        .||.  |||:|          ..|........|.| :.|
Human    61 AWRNHTVPLRLRDGREVP--------HSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGW 117

  Fly   100 -----------IYHYDHG-------------FISMNADLNWVCDDAYKARVGQSLFFVGSMCGTL 140
                       :...|.|             .:.:.|..|.||:|.:||.:..||||||.:.|:.
Human   118 EFSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSF 182

  Fly   141 LFGLLGDRIGR--IKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLMFILVLEY 203
            :.|.|.||.||  :..|.:....||  ....||::....|.....:.|:...:|....|:|..|.
Human   183 ISGQLSDRFGRKNVLFVTMGMQTGF--SFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEI 245

  Fly   204 VSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVT 268
            :..::|.:...|.:|:||..|.:.......::..||..:|...:|.:|....::.|.||.:||::
Human   246 LGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLIS 310

  Fly   269 RQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARSQMSMQKQA-RLIDSFKLPRLRL 332
            :..|:.||:.:|:.||.|...|....::         .||.:...|.::|: .::|..:...:|:
Human   311 QGRFEEAEVIIRKAAKANGIVVPSTIFD---------PSELQDLSSKKQQSHNILDLLRTWNIRM 366

  Fly   333 RLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSM 397
            ..|...:::..:::.|..:|.:...|....||...|.|:...|:.:....:.::..|:::
Human   367 VTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYS----- 426

  Fly   398 TATGLMTATTGILLAFW------TQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSG 456
            .||.|...  |.:|.|.      ..:.|||:|   ::.:||::.........:.||.||.||:.|
Human   427 MATALFLG--GSVLLFMQLVPPDLYYLATVLV---MVGKFGVTAAFSMVYVYTAELYPTVVRNMG 486

  Fly   457 LAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTL 515
            :.|....:...|.:||:.::|..|.|....|:...|.:::|.:.|.|.|:....||.|:
Human   487 VGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTI 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	130/567 (23%)
		MFS	129..503	CDD:119392	94/382 (25%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	130/567 (23%)
		MFS	162..534	CDD:119392	97/392 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950