Protein Alignment CG14856 and SLC22A4

DIOPT Version :9

• Sequence 1: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_003050.2
• Gene: SLC22A4 / 6583
• HGNCID: 10968
• Length: 551
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 126/564 - (22%)
• Similarity: 242/564 - (42%)
• Gaps: 60/564 - (10%)

  Fly     4 DFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVI--GFVPDHWCYHEQLENRSYA---- 62
            |:||::...|:...:|.::..|  |...|:...:...:|:  ...|:|.|......|.|.|
Human     3 DYDEVIAFLGEWGPFQRLIFFL--LSASIIPNGFNGMSVVFLAGTPEHRCRVPDAANLSSAWRNN 65

  Fly    63 ----------EIAAIYAPFKRPSCT--RLASI----------NMDGSNATASSEPC-NRWIYHYD 104
                      |:.        .||:  |||:|          ..|........|.| :.|.:..|
Human    66 SVPLRLRDGREVP--------HSCSRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQD 122

  Fly   105 HGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDS-A 168
            ....::..:.|.||:|.:|..:..||||||.:.|:.:.|.|.||.|| |.|:.|......|.| .
Human   123 VYLSTVVTEWNLVCEDNWKVPLTTSLFFVGVLLGSFVSGQLSDRFGR-KNVLFATMAVQTGFSFL 186

  Fly   169 TIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGV 233
            .||:.:...|:....:.|:...:|..:.|||..|.:..::|.:...|.:|.|:.:|.:.......
Human   187 QIFSISWEMFTVLFVIVGMGQISNYVVAFILGTEILGKSVRIIFSTLGVCTFFAVGYMLLPLFAY 251

  Fly   234 WLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELF 298
            ::..||..::...:|.:|....::.|.||.:||::::.|..||..:::.||.|...|....::..
Human   252 FIRDWRMLLLALTVPGVLCVPLWWFIPESPRWLISQRRFREAEDIIQKAAKMNNIAVPAVIFDSV 316

  Fly   299 RQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPF 363
            .:....|          |::|.::|.|:...:.:..|...:::.:.::.|..:|.:...|....:
Human   317 EELNPLK----------QQKAFILDLFRTRNIAIMTIMSLLLWMLTSVGYFALSLDAPNLHGDAY 371

  Fly   364 VMFSLFALTLPPSGIFQTQVQKHFGRKF-TSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLL 427
            :...|.||...|:.|....:.:...|:: .:.|.....|::.....:.:.::     .:.:.|::
Human   372 LNCFLSALIEIPAYITAWLLLRTLPRRYIIAAVLFWGGGVLLFIQLVPVDYY-----FLSIGLVM 431

  Fly   428 MCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCIL 492
            :.:|||:.........:.||.||.||:..:.|....:...|.|:|:.::|..|.|....|:...|
Human   432 LGKFGITSAFSMLYVFTAELYPTLVRNMAVGVTSTASRVGSIIAPYFVYLGAYNRMLPYIVMGSL 496

  Fly   493 LLVSAWICLLLSETRNKKLPLTLAEGEE---FGKGERMFDFMRS 533
            .::...:.|...|:....||.||.:.::   |..|::..|.|.:
Human   497 TVLIGILTLFFPESLGMTLPETLEQMQKVKWFRSGKKTRDSMET 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	117/531 (22%)
		MFS	129..503	CDD:119392	85/375 (23%)
SLC22A4	NP_003050.2	2A0119	12..518	CDD:273328	117/531 (22%)
		MFS	123..508	CDD:119392	90/400 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153707
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950