DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and SLC22A2

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_003049.2	Gene:	SLC22A2 / 6582	HGNCID:	10966	Length:	555	Species:	Homo sapiens

Alignment Length:	572	Identity:	133/572 - (23%)
Similarity:	231/572 - (40%)	Gaps:	95/572 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYH---EQLENR--- 59
            |....|::|...|:.|.:|..:..|..||....:..|.....:||.|||.|..   .:|..|
Human     1 MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGW 65

  Fly    60 SYAEIAAIYAPFKRPS-------CTR---------------LASINMDGSNATASSEPC-NRWIY 101
            |.||......|...|:       |.|               |||::.:.|.....  || :.|:|
Human    66 SPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLG--PCRDGWVY 128

  Fly   102 HYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGR---IKAVVLANCCGF 163
            .....  |:..:.|.||.:::...:.||...||...|::..|.:.||.||   :...||.|..
Human   129 ETPGS--SIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAA-- 189

  Fly   164 LGDSATIFAETLLTFSAS-------RFVSGLAAEANSYLMFILVLEYVSPT-MRSVGLNLTMCVF 220
                    |..|:..|.:       |.:.||.::|...:.:||:.|:|... .|:||:...  |.
Human   190 --------AGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQ--VA 244

  Fly   221 YGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKF 285
            |.:|::..:.....|..||......:||......:|:.|.||.:||:::.....|...::.:||.
Human   245 YTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKK 309

  Fly   286 NRRDVSEADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNT 350
            |.:.:..:     .|..:.:|...:     :.....:|..:.|::|..    |::     |.||.
Human   310 NGKSLPAS-----LQRLRLEEETGK-----KLNPSFLDLVRTPQIRKH----TMI-----LMYNW 355

  Fly   351 MSRNV--EGLSI-------SPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTAT 406
            .:.:|  :||.:       :.::.|...||...|:...........||::....|....| ....
Human   356 FTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAG-AACL 419

  Fly   407 TGILLAFWTQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAAL---S 468
            ..:.:....|....::.||   .|.||::.......::.||.||.:|:.|   :|:.::..   .
Human   420 ASVFIPGDLQWLKIIISCL---GRMGITMAYEIVCLVNAELYPTFIRNLG---VHICSSMCDIGG 478

  Fly   469 FISPFILH-LDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAEGE 519
            .|:||::: |...:.....::..:|.||:..:.|||.||:.|.||.|:.|.|
Human   479 IITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	127/553 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	85/397 (21%)
SLC22A2	NP_003049.2	2A0119	13..525	CDD:273328	127/553 (23%)
SLC22A2	NP_003049.2	MFS	124..492	CDD:119392	88/407 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950