Protein Alignment CG14856 and SLC22A3

DIOPT Version :9

• Sequence 1: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 140/569 - (24%)
• Similarity: 242/569 - (42%)
• Gaps: 87/569 - (15%)

  Fly     5 FDEILVKCGDSHRYQ---YMLLALYGLLMFIVSRHYFAQNVIGFV-----PDH-WC--------- 51
            |||.|.:.|:..|:|   ::||.|.|:.        ||...:|.|     ||| ||
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVT--------FAFLFVGVVFLGTQPDHYWCRGPSAAALA 60

  Fly    52 -----YHEQLENRSYAEIAAIYAPFKRPSCTR--LASINMDGSNATASSE--------------- 94
                 ..|:..||:.........|.:|..|.|  |.:.| |.::||::..
Human    61 ERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAAN-DSASATSALSCADPLAAFPNRSAPL 124

  Fly    95 -PC-NRWIYHYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVL 157
             || ..|.|...|..|....||  ||.:|:...:.|::..:|.:.|....|...||.||| .:.|
Human   125 VPCRGGWRYAQAHSTIVSEFDL--VCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRI-VIYL 186

  Fly   158 ANCCGFLGDSATI--FAETLLTFSASRFVSGLAAEANSYLMFILVLEYV-SPTMRSVGLNLTMCV 219
            .:|.| :|.:..:  ||.....|...||:.|:..:......:::|.|.| |...|.||:.:.|
Human   187 LSCLG-VGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQM-- 248

  Fly   220 FYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAK 284
            |:.||:|.......::.:|:...:...||..|...:|:::.||.:||:||:..|.|...|||:||
Human   249 FFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAK 313

  Fly   285 FNRRDVSEADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYN 349
            .|.:.:|....|:      |...|..|..|      .:|..:.|::|...:.:...:....:.|.
Human   314 CNGKYLSSNYSEI------TVTDEEVSNPS------FLDLVRTPQMRKCTLILMFAWFTSAVVYQ 366

  Fly   350 TMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFW 414
            .:...:..:..:.::.|.:..:...|..:......:..||:    :...|:.::.....::.||.
Human   367 GLVMRLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRR----LPFAASNIVAGVACLVTAFL 427

  Fly   415 TQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDT 479
            .:..|.:...:..:.|.||::.......:::||.||.:|:.|:::..........|:||:|
Human   428 PEGIAWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLL---- 488

  Fly   480 YFRAAS------SIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFG 522
             ||.|:      .||..||..:...:.:||.||:...||.|:.:.|:.|
Human   489 -FRLAAVWLELPLIIFGILASICGGLVMLLPETKGIALPETVDDVEKLG 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	133/551 (24%)
		MFS	129..503	CDD:119392	87/382 (23%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	133/551 (24%)
		MFS	149..518	CDD:119392	90/393 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950