Protein Alignment CG14856 and SLC22A1

DIOPT Version :9

• Sequence 1: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 134/561 - (23%)
• Similarity: 230/561 - (40%)
• Gaps: 105/561 - (18%)

  Fly     6 DEILVKCGDSHRYQ---YMLLALYG-----LLMFIVSRHYFAQNVIGFVPDHWCYH---EQLENR 59
            |:||.:.|:|..:|   :::|.|..     :.:.||        .:||.|||.|..   .:|..|
Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIV--------FLGFTPDHHCQSPGVAELSQR 61

  Fly    60 ---SYAEIAAIYAPFKRPS-------CTR---------LASINMDGSNATASSE----PC-NRWI 100
               |.||......|...|:       |.|         |:.::...|.||..|.    || :.|:
Human    62 CGWSPAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWV 126

  Fly   101 YHYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGR---IKAVVLANC-C 161
              ||....|:..:.|.||.|::|..:.||....|.:.|:|..|...||.||   :...||.|. .
Human   127 --YDTPGSSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVS 189

  Fly   162 GFLGDSATIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYV-SPTMRSVGLNLTMCVFYGLGM 225
            |.|    ..|:...::....|.:.||.::.|....:.|:.|:| |.:.|:|.:...|.  :.:|:
Human   190 GVL----MAFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMA--FTVGL 248

  Fly   226 ICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDV 290
            :..:.....|..||...:..:||..|...:|:.:.||.:||::::....|...:..:|:.|.: :
Human   249 VALTGLAYALPHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGK-L 312

  Fly   291 SEADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNV 355
            ..||.::.     :.|.:...::|    ....|.|:.||||.|...:..::...::.|..:..::
Human   313 PPADLKML-----SLEEDVTEKLS----PSFADLFRTPRLRKRTFILMYLWFTDSVLYQGLILHM 368

  Fly   356 EGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAF------W 414
            ...|.:.::.|...||...|............||    :..|..:.|:.....:::.|      |
Human   369 GATSGNLYLDFLYSALVEIPGAFIALITIDRVGR----IYPMAMSNLLAGAACLVMIFISPDLHW 429

  Fly   415 TQHSATVMVCLLLMC--RFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHL 477
            ..        :::||  |.||::.......::.||.||.||:.|:.|..........|:|||:
Human   430 LN--------IIIMCVGRMGITIAIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIV-- 484

  Fly   478 DTYFRAASSIITCILLLVSAW--ICLLLSETRN-KKLPLTL 515
               ||           |...|  :.|:|.|.:: ||...||
Human   485 ---FR-----------LREVWQALPLILFEKQSPKKTRFTL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	129/551 (23%)
		MFS	129..503	CDD:119392	86/388 (22%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	125/540 (23%)
		MFS	118..484	CDD:119392	92/395 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950