DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and SLC22A23

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_011513103.1	Gene:	SLC22A23 / 63027	HGNCID:	21106	Length:	710	Species:	Homo sapiens

Alignment Length:	678	Identity:	140/678 - (20%)
Similarity:	243/678 - (35%)	Gaps:	186/678 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMDFDEILVKC--GDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSY-- 61
            :.:|:|..::..  |....||..|:.|..:....:....|:.:.:...|:.||       |..
Human    76 LLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWC-------RGAGK 133

  Fly    62 -AEIAAI---------------------YAPFKRPSCTRLASINMDGSNA-----------TASS 93
             .|:|.:                     .||::... .|..|...||.:.           .||:
Human   134 GTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAG-NRSNSSGADGGDTPPLPSPPDKGDNASN 197

  Fly    94 EPCNRWIYHYDHGFIS-----------------------MNADLNW--VCDDAYKARVGQSLFFV 133
            ..|..|.|....|.:.                       ...:|||  |||:|:|..:.:....|
Human   198 CDCRAWDYGIRAGLVQNVVSKCCQQQETGALPWDTDTKRWRPELNWDLVCDNAWKVHIAKFSLLV 262

  Fly   134 GSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLT-FSASRFVSGLAAEANSYLMF 197
            |.:.|.|:.|.:.|.:|| :.|:|.:....|....|:.....:| ||..||..|.........::
Human   263 GLIFGYLITGCIADWVGR-RPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLY 326

  Fly   198 ILVLEYVSPTMRSVGLNLTMCVFY----------GLGMICASWQGVWLGSWRSFMVWTAL---PQ 249
            .|.:|...|..|.:   :||...:          ||..:|..||           |..||   |.
Human   327 ALRIELCPPGKRFM---ITMVASFVAMAGQFLMPGLAALCRDWQ-----------VLQALIICPF 377

  Fly   250 LLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRD--------VSEADYELFRQHCKTKE 306
            ||:..::.:..||.:||:..|.|:.|:..:....:.||.:        :.|.:.||.|:..|...
Human   378 LLMLLYWSIFPESLRWLMATQQFESAKRLILHFTQKNRMNPEGDIKGVIPELEKELSRRPKKVCI 442

  Fly   307 SEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTM---------SRNVEGLSISP 362
            .:.....::.|                        :||.||.|::         :|::.|..:..
Human   443 VKVVGTRNLWK------------------------NIVVLCVNSLTGYGIHHCFARSMMGHEVKV 483

  Fly   363 FVMFSLFALTLPPSGIFQTQ------VQKHFGRK--------FTSVVSMTATGLMTATTGILLAF 413
            .::.:.:|.....:.|....      |.:..||:        .|::.|:...||:.     |:..
Human   484 PLLENFYADYYTTASIALVSCLAMCVVVRFLGRRGGLLLFMILTALASLLQLGLLN-----LIGK 543

  Fly   414 WTQHSATVM---------VCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSF 469
            ::||..:.|         :...::..|........::....|:.||.:|..||.::..:|.....
Human   544 YSQHPDSGMSDSVKDKFSIAFSIVGMFASHAVGSLSVFFCAEITPTVIRCGGLGLVLASAGFGML 608

  Fly   470 ISPFI-LHLDT-YFRAASSIITCILLLVSAWIC-LLLSETRNKKLPLTLAEGEEF--------GK 523
            .:|.| ||... ||........|.|:.:   || |||.|:|::.||..::.||.:        .|
Human   609 TAPIIELHNQKGYFLHHIIFACCTLICI---ICILLLPESRDQNLPENISNGEHYTRQPLLPHKK 670

  Fly   524 GERMFDFMRSFKK--ADQHDLSA--DTI 547
            ||:......:..|  :..||.:|  ||:
Human   671 GEQPLLLTNAELKDYSGLHDAAAAGDTL 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	127/617 (21%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	89/430 (21%)
SLC22A23	XP_011513103.1	2A0119	<243..652	CDD:273328	100/455 (22%)
SLC22A23	XP_011513103.1	MFS	259..>388	CDD:119392	35/143 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153280
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030