Protein Alignment CG14856 and SLC22A15

DIOPT Version :9

• Sequence 1: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_060890.2
• Gene: SLC22A15 / 55356
• HGNCID: 20301
• Length: 547
• Species: Homo sapiens
• Alignment Length: 575
• Identity: 129/575 - (22%)
• Similarity: 221/575 - (38%)
• Gaps: 89/575 - (15%)

  Fly     3 MDFDEILVKCGDSHRYQ-YMLLALYGLLMFIVSRHYFAQNVIGFVPD-HWCYHEQLENRSYAEIA 65
            |:.:|.....|:...|| |:...|..||...|:.......::|..|. ||...|.|.|:|:
Human     1 MEVEEAFQAVGEMGIYQMYLCFLLAVLLQLYVATEAILIALVGATPSYHWDLAELLPNQSH---- 61

  Fly    66 AIYAPFKRPSCTRLASINMDGSNATASSEPCNRWI-----------YHYDHGFISMNADLNWVCD 119
                                |:.:....:....|:           .|:...|.|:.::...:.:
Human    62 --------------------GNQSAGEDQAFGDWLLTANGSEIHKHVHFSSSFTSIASEWFLIAN 106

  Fly   120 DAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFV 184
            .:||.....|.||.|...|.:.||.|.||.||.|..:.......|...|..|:.:...|:.:||:
Human   107 RSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFL 171

  Fly   185 SGLAAEANSYLMFILVLEYVSPT----MRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWT 245
            .|:.....|.:.|:|:.|.|...    ..|:|     .:|:.:|:...:..|.::.|||:..:..
Human   172 VGMMNGGMSLVAFVLLNECVGTAYWALAGSIG-----GLFFAVGIAQYALLGYFIRSWRTLAILV 231

  Fly   246 ALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEAR 310
            .|...:|......|.||.:||.::.....||..|..:||.||:  .:..:.|...
Human   232 NLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALYLIAKRNRK--LKCTFSLTHP---------- 284

  Fly   311 SQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPP 375
            :..|.::....:|.|:...|....:.:..::.:.:|.|..::.:...|..|.:...:|..|...|
Human   285 ANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIP 349

  Fly   376 S---GIFQTQVQKHFGRKFTSVVSMTATGLM---------TATTGILLAFWTQHSATVMVCLLLM 428
            |   .|:... ||.||||.|....:...||.         ...||: .|....||.:::..|.:.
Human   350 SYPLCIYLIN-QKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGV-FAVVNSHSLSLLGKLTIS 412

  Fly   429 CRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILL 493
            ..|.|      ....::||.||.:|:.||....:.:.....|:|||..|.....:...|:.....
Human   413 AAFNI------VYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATG 471

  Fly   494 LVSAWICLLLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIE 548
            |.|..:.|||.||.|..|..|.::.:.:           |:::..:..||...::
Human   472 LTSGLLSLLLPETLNSPLLETFSDLQVY-----------SYRRLGEEALSLQALD 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	123/529 (23%)
		MFS	129..503	CDD:119392	94/389 (24%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	91/382 (24%)
		MFS_1	111..450	CDD:284993	86/363 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	522..547

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850