DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and slc22a15.1

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_031751719.1	Gene:	slc22a15.1 / 448510	XenbaseID:	XB-GENE-959503	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	129/557 - (23%)
Similarity:	207/557 - (37%)	Gaps:	115/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQ-YMLLALYGLLMFIVSRHYFAQNVIGFVPD-HWCYHEQLENRSYAEIA 65
            |:.:..|...|:...|| |:...|..||....:.......::|..|. ||.......|.|..:
Frog    27 MEVEGALKLVGEMGIYQIYLSFLLAVLLQLYSATEAIIITILGATPPYHWMNDSLTANGSRGK-- 89

  Fly    66 AIYAPFKRPSCTRLASINMDGSNATASSEPCNRWIYH----YDHGFISMNADLNWVCDDAYKARV 126
                              ..||...|..|       |    :|..|.|:.::...|...||:..|
Frog    90 ------------------QYGSQLPAEGE-------HGHVVFDGNFTSIVSEWFLVGGAAYEVSV 129

  Fly   127 GQSLFFVGSMCGTLLFGLLGDRIGR----IKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGL 187
            ..|::|.|.:.|.:.||.|.||.||    :..:.|......:.....||...|||    ||:.|:
Frog   130 SSSVYFGGVLIGVISFGQLSDRFGRKPVYVTGLALEVVFAVMNALTPIFPLFLLT----RFLVGV 190

  Fly   188 AAEANSYLMFILVLEYVSPTMRSVGLNL-TMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLL 251
            .....|.:.|:|:.|.:..:..:...:| ::|  :.:|:...:..|.::.|||...:...:....
Frog   191 MNGGMSLVAFVLLNECIGASYWAAAGSLGSLC--FAVGIAQFALIGYFIRSWRLLALLVNVQGAA 253

  Fly   252 VTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARSQMSMQ 316
            |......|.||.:||..:.....|:..|..:.:.|||.|:  .:.|    |..::..|.|
Frog   254 VLALSLCIPESPRWLHAQGRLREAQESLLSLGRRNRRKVT--SFTL----CPRQKDSAHS----- 307

  Fly   317 KQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQT 381
              |.::..:....||.|.:.:..|:.:.:|.|       .||::|...:.....|.|..||:.:.
Frog   308 --ANILTIYSNAILRQRTLIMMWVWFVCSLVY-------YGLTLSSGDLGGDIYLNLALSGLAEL 363

  Fly   382 QV---------QKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFG----- 432
            ..         .|..||:                 |.|..|......   .|||:|...|
Frog   364 PAYPLCMYLINHKRVGRR-----------------GSLAGFLCVGGG---ACLLIMLVPGKTGSG 408

  Fly   433 -ISVTTGSTMQI----------------STELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTY 480
             :||....|:.:                |:||.|||||:.|:.|..:.:.....|:|||..|...
Frog   409 PLSVLNSQTLSLLGKLNISAAFNIVYIYSSELYPTCVRNLGMGVCSMFSRIGGIIAPFIPALRFA 473

  Fly   481 FRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAE 517
            ..|...|:.....:.:..:.|||.||.:..||.|||:
Frog   474 HWALPFIVFGAAGVSAGLLSLLLPETLSAPLPETLAD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	124/542 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	93/409 (23%)
slc22a15.1	XP_031751719.1	MFS	90..497	CDD:421695	106/459 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920