DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Orct

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	140/575 - (24%)
Similarity:	240/575 - (41%)	Gaps:	59/575 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWC---YHEQLENRSYAEI 64
            |.:|:::...|:...||..:..|..|...:.:.|..|...:...||..|   |    ||.|..|:
  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPY----ENGSIYEL 61

  Fly    65 AAIYAPFKRPSCTRLASINMD-------GSNATASSE--PCNRWIYHYDHGFISMNADLNWVCDD 120
            :........|...|.:..::|       ||...:|:|  .|:.::|.......|...:.|.||..
  Fly    62 SPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSR 126

  Fly   121 AYKARVGQSLFFVGSMCGTLLFGLLGDRIGR----IKAVVLANCCGFLGDSATIFAETLLTFSAS 181
            :..:....|||.:|.:.|:|:||.:.|::||    ..::||....|.|    ...|....:::.|
  Fly   127 SLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVL----AAVAPEYFSYTIS 187

  Fly   182 RFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTA 246
            |.:.|........:.:::.||.|..:.| :...:.|.:|:.:|.:..:....::..||...:...
  Fly   188 RMIVGATTSGVFLVAYVIALEMVGSSYR-LFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAIT 251

  Fly   247 LPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARS 311
            ||.||...:|::|.|||:||:.:...|.|.:.:.:.||.|:.:|....||........|:.:...
  Fly   252 LPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEM 316

  Fly   312 QMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPS 376
            ..| |..|.:.|..:.|.||.:.:.:...:.:.:..|..:|.|...|..:..|.|.:......|.
  Fly   317 AAS-QPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPG 380

  Fly   377 GIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMV-----CLLLMC----RFG 432
            ..........:||:     |:....:|.|...:|        ||:.|     .|::.|    :..
  Fly   381 YTLLLFTLNRWGRR-----SILCGTMMVAGISLL--------ATIFVPSDMNWLIVACAMIGKLA 432

  Fly   433 ISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSA 497
            |:.:.|:....|.|..||.||:.||....:.|.....::|::..|...:|....||...|.|.:.
  Fly   433 ITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAG 497

  Fly   498 WICLLLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIEKLMG 552
            .:.|||.||.||.:|.|:.:||.|||           |.|.|........::|.|
  Fly   498 LLSLLLPETLNKPMPETIEDGENFGK-----------KPAPQETAEEGGTQELSG 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	127/525 (24%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	92/386 (24%)
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	127/525 (24%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	89/374 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	4	3.940