DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG6231

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001262734.1	Gene:	CG6231 / 42339	FlyBaseID:	FBgn0038720	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	287/549 - (52%)
Similarity:	388/549 - (70%)	Gaps:	8/549 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            ||||:||.||||.:|||:|:|||:|.:..|||.|||.|.||.|||||||||::|.|.:|.||..|
  Fly     1 MDFDQILAKCGDFNRYQFMILALFGFINIIVSMHYFTQTVISFVPDHWCYHDKLVNMTYKEIGEI 65

  Fly    68 YAPFKRPSCTRLASINMDGSNATASSEPCNRWIYHYDHGFISMNADLNWVCDDAYKARVGQSLFF 132
            ||.|:.||||||..||  |.|.|.||:.|.:|||:||.|:.|||.:||||||.|||||:||||||
  Fly    66 YAQFENPSCTRLDDIN--GHNVTVSSKACEKWIYNYDFGYRSMNTELNWVCDSAYKARIGQSLFF 128

  Fly   133 VGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLMF 197
            :||:.|||.:|||.|:|||:.|::|:|.|||.||.:|||.:::.||:..||:|||||:.|.|||:
  Fly   129 IGSVVGTLFYGLLSDKIGRVPALILSNFCGFAGDFSTIFTKSVATFTLCRFISGLAADTNFYLMY 193

  Fly   198 ILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQES 262
            |:||||:.|:||::|||:.:.:||.||::...|..|.:|.|:.::..|:||.|||..:||::|||
  Fly   194 IIVLEYIRPSMRTLGLNMAVGLFYCLGLVFTPWLAVLVGHWQIYLACTSLPILLVVLYYFVVQES 258

  Fly   263 AQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCK-TKESEARSQMSMQKQARLIDSFK 326
            |||||||.|.|||.:||:||||||...||:||::.||:||: |.|......   :|||.|:|.|:
  Fly   259 AQWLVTRNDIDGAIVRLKRVAKFNGCRVSQADFDEFRRHCQMTHEMLGGDD---KKQATLLDMFR 320

  Fly   327 LPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKF 391
            .||:|...:.:.....::||||:.:||||||:.||||:||||.||.:.||.:....:|...|||.
  Fly   321 TPRMRKNTLILFFKSMVITLCYDAVSRNVEGMGISPFIMFSLSALAVLPSSVLLVLLQDRIGRKG 385

  Fly   392 TSVVSMTATGLMTATTGILLAFWT-QHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSS 455
            .:..|:...||.||..||.:|:.. .|:|.::.||.:..|||::::..|..|.:|||:|||||..
  Fly   386 MASGSLLVGGLFTAAAGIAIAYQQHNHNAILLACLTIAARFGVAISYESGSQYATELIPTCVRGQ 450

  Fly   456 GLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEE 520
            |:|.:||...|.||::|:||.|.|:|:||.|||..:|....:::||||.||.|:.||.|:.|||.
  Fly   451 GVAAVHVAGFAASFLAPYILWLGTFFKAAPSIILGVLFFAGSFVCLLLPETLNRSLPTTIEEGEV 515

  Fly   521 FGKGERMFDFMRSFKKADQHDLSADTIEK 549
            ||||||||||.....|.|..: |...:||
  Fly   516 FGKGERMFDFPCLHNKHDDEE-SESELEK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	260/502 (52%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	180/375 (48%)
CG6231	NP_001262734.1	2A0119	11..509	CDD:273328	260/502 (52%)
CG6231	NP_001262734.1	MFS	125..499	CDD:119392	181/376 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471361
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.860