DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG16727

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	213/546 - (39%)
Similarity:	328/546 - (60%)	Gaps:	14/546 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            ||||.:|.|||:..|:|:::|.|||....:.|.|||:|.:|.|.|:|||.|:.|.....||:.:|
  Fly     1 MDFDRVLEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTPEHWCSHDDLMGLGAAELRSI 65

  Fly    68 YAPFKRPSCTRLASINMDGSNATASSEPCNRWIYHYDHGFISMNADLNWVCDDAYKARVGQSLFF 132
            |:....||||.|:.: ::|: ..||.|.|..||:..::|:.|:..:|.||||.:::..||||.||
  Fly    66 YSNVSHPSCTLLSEV-INGT-GVASEESCQDWIFERENGYESLTTELKWVCDKSHQPAVGQSFFF 128

  Fly   133 VGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLMF 197
            :||:.||:.||.|.|.|||:.|:::|...|..||..|.|..||..|:.|||||||:.:...|||:
  Fly   129 LGSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLPWFAFSRFVSGLSTDTMYYLMY 193

  Fly   198 ILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQES 262
            |||.||:||..|:.|||:.:.|||..|::.:.|..:|:|:||.::...:||.|.|..:..||.||
  Fly   194 ILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYLWLASLPALGVLIYPLLICES 258

  Fly   263 AQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTK---ESEARSQMSMQKQARLIDS 324
            ||||:|::.:|.|...|::|||||.|.|.::.::.|.:|.:.|   ||:...||.     ..:..
  Fly   259 AQWLLTKKKYDEAVACLKKVAKFNGRQVEDSVFDEFVKHYREKMNEESKLNKQMD-----TFLGM 318

  Fly   325 FKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGR 389
            ||.||||.....:.|...|:||.|:.::||:|||..|||.:|||.:....|:|.....:|...||
  Fly   319 FKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLGSSPFKLFSLTSSVYLPAGFTILLLQNKIGR 383

  Fly   390 KFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLL-MCRFGISVTTGSTMQISTELMPTCVR 453
            |..:..::....::||.||.|:|........|::.|:: :.|||.:|:..:.:|.:.|::||.||
  Fly   384 KGMACGALLVGAIITAVTGFLIAVLDPSENAVLLALMVGLGRFGTTVSYDAEIQYAAEIIPTSVR 448

  Fly   454 SSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAEG 518
            ...::.|||...|.|.::.::::|..|::...||...:|:.:.|.:||.|.||.:||||.|||:|
  Fly   449 GQAVSNIHVVGLASSSLAFYVIYLAQYYKPLPSIFISVLMFLGALLCLTLPETLHKKLPETLADG 513

  Fly   519 EEFGKGERMFDFMRSFKKAD---QHD 541
            |.|...|....|....|:.:   :|:
  Fly   514 ERFAMNESCLYFPCLHKRRESLTEHE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	196/504 (39%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	143/377 (38%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	196/504 (39%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	143/378 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471379
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.860