DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG17752

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_650817.1	Gene:	CG17752 / 42337	FlyBaseID:	FBgn0038718	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	209/555 - (37%)
Similarity:	310/555 - (55%)	Gaps:	33/555 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLE-NRSYAEIAA 66
            ||...:|.|||:...||.:||.|||....:.|.|||:|.:|.|.|.|.|.....| ::::.|:.
  Fly     1 MDLQRVLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLISFTPSHRCSAPVEEFSQNFTELL- 64

  Fly    67 IYAPFKRPSCTRLASINMDGSNATASSEPCNRWIYHYDHGFISMNADLNWVCDDAYKARVGQSLF 131
                    ||   :.|..|....:.....|:.|.:..:..:.|:..:|.||||||||..||||.|
  Fly    65 --------SC---SVIQYDVDMTSFRDNKCSSWDFDKESNYESITTELEWVCDDAYKLAVGQSFF 118

  Fly   132 FVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLM 196
            |:||..|::.||.|.|||||:.|.||:...|..||..|.|..:|..||.:||:|||:.:....||
  Fly   119 FIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFVGSLPMFSFTRFISGLSMDTQYVLM 183

  Fly   197 FILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQE 261
            :|||.||:||..|:.|||:.:.|||.:|::.:.|..:|||:|||::...:||.|.:..|...:.|
  Fly   184 YILVFEYLSPQHRTFGLNIILGVFYSIGLMISPWIAIWLGNWRSYLWAASLPALGMLIFPLFLHE 248

  Fly   262 SAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARSQMSMQKQARLIDSF- 325
            |.:||:|:..||.|...|:.|||||.|.|.::.::.|.:|.:.|.:.|:.:.|        |:|
  Fly   249 SVEWLLTKGKFDKAVNNLKSVAKFNGRQVEDSVFDEFIKHYREKLNSAQKKSS--------DTFM 305

  Fly   326 ---KLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHF 387
               :.||||...|.:.:...|:|:.::.:||||||:.||||.:||.....:.|.|:.....|...
  Fly   306 GMLRTPRLRKFTIILLIKSMIITIAFDILSRNVEGVGISPFKLFSYSGFVVLPGGLSIILFQNKI 370

  Fly   388 GRKFTSVVSMTATGLMTATTGILLAFWTQHSATV----MVCLLLMCRFGISVTTGSTMQISTELM 448
            |||..:..|:.....:|||||.|:......:.:|    ||||   .|||..|...:..|.:.|::
  Fly   371 GRKGMACASLLVGAFITATTGYLVGTLDPANYSVLLGFMVCL---ARFGAVVAYDAEAQYAAEII 432

  Fly   449 PTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPL 513
            ||.||..|:|.|||...|.:|.|.:|::|.|:::...|::...||::.|.:||.|.||.:|:||.
  Fly   433 PTSVRGRGVANIHVVGNAFAFFSSYIIYLGTFYKPLPSLLISFLLIIGACLCLTLPETLHKQLPQ 497

  Fly   514 TLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIE 548
            ||.|||.|.|||:.: |...|.:..|.:.|...:|
  Fly   498 TLEEGEIFAKGEKWY-FFPCFSRKRQSNKSESQLE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	190/509 (37%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	145/381 (38%)
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	190/509 (37%)
CG17752	NP_650817.1	MFS	116..488	CDD:119392	145/382 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471374
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.850