DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG14857

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_650392.1	Gene:	CG14857 / 41791	FlyBaseID:	FBgn0038262	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	552	Identity:	276/552 - (50%)
Similarity:	385/552 - (69%)	Gaps:	13/552 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            ||||:||.|||.:.||||:::.|.|.:.|..:.||::||:|||||.||||||.|||||:.|||||
  Fly     1 MDFDQILEKCGSAGRYQYLMILLLGYIAFTTTVHYYSQNIIGFVPQHWCYHEALENRSFEEIAAI 65

  Fly    68 YAPF-KRPSCTRLASINMDGSNATASSEPCNRWIYHYDHGFISMNADLNWVCDDAYKARVGQSLF 131
            |||| |..|||||..|  :|...|.|:|.|.||||:||.||.||||:|||||:||||||:|||||
  Fly    66 YAPFGKEASCTRLDKI--EGDRVTVSNETCQRWIYNYDFGFRSMNAELNWVCNDAYKARIGQSLF 128

  Fly   132 FVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLM 196
            |:||:.||..||:|||||||::||:|||.|||:||..|.:|..|:.|:..|.:|||||.||.|||
  Fly   129 FLGSLMGTFTFGVLGDRIGRVRAVILANQCGFVGDFLTTYASNLVQFAIFRCISGLAATANYYLM 193

  Fly   197 FILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQE 261
            |||||||::|.:|::.::.|:.:.:.||.:.|.|..|..|:||.::..:||.||:|..|||::||
  Fly   194 FILVLEYLAPKLRNMAISGTLGICFCLGALVAPWLSVLAGNWRIYLTCSALLQLVVALFYFVVQE 258

  Fly   262 SAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARSQMSMQKQ--ARLIDS 324
            |||||:||.:.:||..||:.:|.||..:|..||:|.||::|..|.     ::|.|.:  |.:.|.
  Fly   259 SAQWLITRTNVEGAIARLKHIAHFNGMEVKAADFEAFRRNCIVKR-----KLSNQPEQTAGIFDL 318

  Fly   325 FKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGR 389
            .:.|.||...:.|...|.:.:|.:||:||||||:.:||||:|||||:.:||||..|..:|...||
  Fly   319 LRTPNLRKVSLLVVFTFMLTSLSFNTISRNVEGMGLSPFVVFSLFAVVVPPSGFIQGLLQSRVGR 383

  Fly   390 KFTSVVSMTATGLMTATTGILLAF-WTQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVR 453
            |.|:.::|..|||::...|:.|:. ..|.:.|:::...|..|.|||:....|.|.::||:|||||
  Fly   384 KATAFLAMLCTGLLSCALGVALSTEGAQKNVTLLLAFALPMRLGISMCYTVTSQFASELLPTCVR 448

  Fly   454 SSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAEG 518
            |.|:|.:|:.||..||:||:::||.|...||.|:|..:|||.::...|:|.||.|::||:|||:|
  Fly   449 SRGIAAVHLAAAGASFVSPYLIHLGTKLAAAPSLILALLLLTASGCTLMLPETNNRQLPITLADG 513

  Fly   519 EEFGKGERMFDFMRSFKKADQHDLSADTIEKL 550
            |.|||||.|..| ..:::.|. |:|.:..|::
  Fly   514 EAFGKGESMLSF-DCWRRHDD-DVSKEATEEV 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	252/504 (50%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	172/376 (46%)
CG14857	NP_650392.1	2A0119	11..509	CDD:273328	252/504 (50%)
CG14857	NP_650392.1	MFS	126..470	CDD:119392	161/348 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471359
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BGEV
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	1	1.000	-	-		FOG0006714
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	8	7.860