DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and slc22a6l

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_996960.2	Gene:	slc22a6l / 404609	ZFINID:	ZDB-GENE-040426-2249	Length:	560	Species:	Danio rerio

Alignment Length:	560	Identity:	124/560 - (22%)
Similarity:	239/560 - (42%)	Gaps:	69/560 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCY-HEQLENRSYAEIAA 66
            |.|.::|.:.|.:.|:|.:.:.|..:.:.:::.|...||.:..||.|.|. |..|...|...:..
Zfish     1 MAFSDLLEQVGSTGRFQVLHVTLLSMPILMMASHNLLQNFVAAVPPHHCQPHANLSMSSTDAMDV 65

  Fly    67 IYAPF------KRPSCTR-------LASIN-----MDGSNATASSEPC-NRWIYHYDHGFISMNA 112
            :.|..      |...|.|       :.|:|     .|.|.|...::.| :.|.|:......::..
Zfish    66 LRATVPLGLNGKLERCKRYTTPQWQILSLNTSESLWDESMAETETQSCEDGWFYNMTEMSSTIIT 130

  Fly   113 DLNWVCDDAYKA--RVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETL 175
            :.:.|||  |:|  ::.|:.:..|.:.|.::||.|.||.||...::::|....:|.:...|:.:.
Zfish   131 EWDLVCD--YRALKQMSQTTYMGGVLVGAIVFGGLSDRFGRRVLLLISNLMMAIGGTCVAFSTSF 193

  Fly   176 LTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRS-VGLNLTMCVFYGLGMICASWQGVWLGSWR 239
            ..|...|...|:|........|.|::|::...:|: ||.....|  |..|.:..:.....:..||
Zfish   194 TMFCVFRVCCGMALSGLVLNSFSLIVEWIPTRVRTVVGTGTGYC--YTTGQLILAAVAYCIRDWR 256

  Fly   240 SFMVWTALPQLL--VTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDV--SEADYELFRQ 300
            ...:..:||..:  :..::||  |||:|||..:..:.|...|:.||:.|.|..  .:.|.|:.::
Zfish   257 WLTLAVSLPFYVSFLYSWWFL--ESARWLVLTKKPEQAVKNLKTVARINGRSAEGDKIDLEMLQE 319

  Fly   301 HCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVM 365
            ..|.:.:.::...|      .:|..:...:|...|.::.|:...:..|..:|.:::...:|.:::
Zfish   320 SMKKEMACSKGSYS------ALDLLRTSTMRTITICLSAVWFSTSFAYYGLSMDLQKFGVSIYLI 378

  Fly   366 FSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLL--- 427
            ..:|.....|:.|..|......||:.:...::...|:|                 :::.||:
Zfish   379 QIIFGAVDIPAKIIVTICMSMLGRRPSQCGALVLAGIM-----------------ILINLLVPSD 426

  Fly   428 --MCRFGISVTTGSTMQIS--------TELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFR 482
              |.|..::|.....:..|        .||.||.:|.||:..:.:.|...:.::|.:|.|...:.
Zfish   427 LQMLRTSLAVIGKGCLAASFNCCYLYAGELYPTVIRQSGMGWVSMMARFGAMVAPMVLLLGDDYP 491

  Fly   483 AASSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFG 522
            .....|.....:||......|.||.::.||.|:.:.::.|
Zfish   492 WIPGFIYGGAPIVSGIFAFFLPETLSQPLPDTIQDIDDRG 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	119/540 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	82/391 (21%)
slc22a6l	NP_996960.2	2A0119	11..523	CDD:273328	119/540 (22%)
slc22a6l	NP_996960.2	MFS	116..513	CDD:119392	90/425 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589032
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950