DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and SLC22A25

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_016873173.1	Gene:	SLC22A25 / 387601	HGNCID:	32935	Length:	577	Species:	Homo sapiens

Alignment Length:	600	Identity:	138/600 - (23%)
Similarity:	250/600 - (41%)	Gaps:	116/600 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMF--IVSRHYFAQNVIGFVPDHWCYHEQLENRSYAE-- 63
            |.|.::|.:.|...|:|  :|.:..|:||  ||......:|...|:.||.|:...|:|.:..:
Human     1 MAFQDLLDQVGGLGRFQ--ILQMVFLIMFNVIVYHQTQLENFAAFILDHRCWVHILDNDTIPDND 63

  Fly    64 --------IAAIYAPFK---RP-SCTRLAS-----INMDGSNATAS---SEPC-NRWIYHYDHGF 107
                    :..|..||.   || .|.|...     |:::|:....|   :||| :.|:  ||...
Human    64 PGTLSQDALLRISIPFDSNLRPEKCRRFVHPQWKLIHLNGTFPNTSEPDTEPCVDGWV--YDQSS 126

  Fly   108 ISMNADLNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDR---------------------- 148
            ........|  ||:......|.:.||..|.|.|..|:|.|.||
Human   127 FPSTIVTKWDLVCESQPLNSVAKFLFMAGMMVGGNLYGHLSDRKPLSSPNHVSTDCDEGLEVPIA 191

  Fly   149 --------IGR--------IKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAEANSYLMF 197
                    .||        ::..::..|..        ||.|:|.:.:.||::|.|..:......
Human   192 IHQHHVFWFGRKFVLRWSYLQLAIVGTCAA--------FAPTILVYCSLRFLAGAATFSIIVNTV 248

  Fly   198 ILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTG---FYFL- 258
            :|::|:::....::.|.||:|        .||...:.|||....:....:.||:::.   .:||
Human   249 LLIVEWITHQFCAMALTLTLC--------AASIGHITLGSLAFVIRDQCILQLVMSAPCFVFFLF 305

  Fly   259 ---IQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKT---KESEARSQMSMQK 317
               :.|||:||:.....:.....||:.|  :|..:..|:..|..:..|:   :|.||     .||
Human   306 SRWLAESARWLIINNKPEEGLKELRKAA--HRNGMKNAEDILTMEVLKSTMKQELEA-----AQK 363

  Fly   318 QARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLF-ALTLPPSGIFQT 381
            :..|.:..::|.:..|:.:::.|....|:.:..::.:::.|..:.|::.:|| |:||..:.:...
Human   364 KHSLCELLRIPNICKRICFLSFVRFASTIPFWGLTLHLQHLGNNVFLLQTLFGAVTLLANCVAPW 428

  Fly   382 QVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLM----CRFGISVTTGSTMQ 442
            .: .|..|:.:.::.|    .:.||..:.:.|..|...|:.|.|..:    ...||:.:|..
Human   429 AL-NHMSRRLSQMLLM----FLLATCLLAIIFVPQEMQTLRVVLATLGVGAASLGITCSTAQ--- 485

  Fly   443 ISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETR 507
             ..||:|:.:|.....:....|.....::..::.|..|.|....||..:..::|..:.|||.|||
Human   486 -ENELIPSIIRGRATGITGNFANIGGALASLMMILSIYSRPLPWIIYGVFAILSGLVVLLLPETR 549

  Fly   508 NKKLPLTLAEGEEFG 522
            |:.|..::.:.|..|
Human   550 NQPLLDSIQDVENEG 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	133/580 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	90/426 (21%)
SLC22A25	XP_016873173.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153666
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940