DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG42269

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	180/573 - (31%)
Similarity:	290/573 - (50%)	Gaps:	44/573 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AMDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPD-HWCYHEQLENRSYAEIA 65
            :||||:||...|:..|||.:|........|.|:..||:|..:..:|: |||:..:|:........
  Fly    69 SMDFDDILPLIGEFGRYQKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLDVEARL 133

  Fly    66 AIYAPFKRPSCTRLASINMDGSNATAS----SEP------CNR-WIYHY-DHGFISMNADLNWVC 118
            |:..|............:::.::..|.    ::|      |.. |.|:: :..:.::..:.||||
  Fly   134 ALSIPMTNGEYNNCYMYDVNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPYATVATEQNWVC 198

  Fly   119 DDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRF 183
            |||......||:||:|::.|.||||.:.||.|||.|::..|..|.|....|.|......|:..||
  Fly   199 DDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAFVSNFWEFAIMRF 263

  Fly   184 VSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMIC-ASWQGVWLGSWRSFMVWTAL 247
            ..|.|.:....:|:|||||||.|..|:...|:::.:|: .|..| ..|...:|..|:...:.|:.
  Fly   264 FVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAIFF-TGAACLLPWIAYFLADWKLLAIVTSA 327

  Fly   248 PQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCK-TKESEARS 311
            |.||.....|::.|||:|||::...|.|...|:::.|.|.|.|....|::|...|| .:|.||::
  Fly   328 PLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQVPPQTYQIFTDSCKRMQEQEAQN 392

  Fly   312 QMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPS 376
                 .:..::|.||.||||...:.:.|::..::|.::...|||..|.:..|..|:|...|..|:
  Fly   393 -----GKYSVLDLFKSPRLRRTTLLLIVIWMAISLVFDGHVRNVGSLGLDIFFTFTLACFTELPA 452

  Fly   377 GIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVM------VCLLLMCRFGISV 435
            ....|.:...|||::.:..||..:|:.:     ||       |||:      ..|.:|.||.:::
  Fly   453 DTLLTVILDRFGRRWLACSSMVLSGVFS-----LL-------ATVVPVGIYSAALAIMGRFFVNI 505

  Fly   436 TTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWIC 500
            :....:|.:.|::||.||:..:|.||:.....|.|:||:::|....:|...||..||.::...:.
  Fly   506 SYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVVYLANISQALPLIILGILGIIGGLLA 570

  Fly   501 LLLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIEKLMGD 553
            |||.||.|..||.||::|||||:|:.::||....|:.|.     |..||...|
  Fly   571 LLLPETLNHVLPQTLSDGEEFGRGQSIWDFPCLAKQVDD-----DEDEKRNAD 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	158/521 (30%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	121/381 (32%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	145/489 (30%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	115/356 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.960