DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG10486

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_647998.2	Gene:	CG10486 / 38664	FlyBaseID:	FBgn0035647	Length:	706	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	150/550 - (27%)
Similarity:	260/550 - (47%)	Gaps:	41/550 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFV-PDHWCY-----HEQLENRSY 61
            :|||::|...|...|:|..|........||.:..|..|..:... |.::||     |..:|.|..
  Fly    94 IDFDDLLPMIGQFGRFQIRLFLFMIPFCFITAFVYLGQIFMCLTPPKYYCYVPELLHTPVELRKE 158

  Fly    62 AEIAAIYAPFKRPSCTRLASINMDGS------------NATASSEPCNR-WIYHYD-HGFISMNA 112
            ..|    ...|..|.:|....|.:.:            |.:..:.||.: :::..: ..|.|...
  Fly   159 LSI----PKEKDGSYSRCRMYNTNYTKIHFAENPSAYINTSLPTIPCKKGYVFEQEGRAFESATM 219

  Fly   113 DLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLT 177
            :..|:|||...|...|.:||:||:.|.|.:|...|..||:.|:|.:.....:|..||..:....|
  Fly   220 EFGWLCDDDKYATYAQIIFFLGSILGGLAYGHFADHCGRVAALVSSCFLALVGSLATSMSTDFFT 284

  Fly   178 FSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFM 242
            |:.|||:.|.:.:....:::|||||||.|..|::..||::.:||....:...|..:..|:||.|.
  Fly   285 FAISRFLVGASYDTCFTMVYILVLEYVGPKYRTLVANLSLALFYSPFTMVMPWIALSAGNWRRFS 349

  Fly   243 VWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCK---T 304
            .:|:||.:|....:.|:.|||:|||:..:.|.|...|:.|.:.|::.||:...:||...|.   .
  Fly   350 SFTSLPIVLAMFSFCLLPESARWLVSVGEIDKALEILKNVIEVNKKQVSKEILDLFEASCTQFYK 414

  Fly   305 KESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGL-SISPFVMFSL 368
            :|.:.|       ...::..||..|:...:|.:.:::..::|.|:...|....| |.:.|:.|::
  Fly   415 EELDGR-------DFTVLSIFKRKRMARYMILMILIWMSISLVYDGHVRAASVLDSENIFLFFTI 472

  Fly   369 FALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGI 433
            ...|..|..|.........||::.|....:.:|:.:     ||....|:.|.:.:. .|..||..
  Fly   473 ACATELPGNILVILTLDRAGRRWCSFFYTSLSGVFS-----LLGASFQNRANMRMS-ALAGRFFS 531

  Fly   434 SVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAW 498
            ::.....:|.:.|::||.||:.|:|.||........:||.:::|.....:::.|:...|.:....
  Fly   532 NICYNIGLQWAAEILPTVVRAQGVAFIHTMGFVAMLMSPPVVYLSKKSLSSTLIVLGALGIFGGL 596

  Fly   499 ICLLLSETRNKKLPLTLAEGEEFGKGERMF 528
            :.|.|.||.|.:||.||::|.:|||.:|::
  Fly   597 LALFLPETLNHELPETLSDGAQFGKNQRIW 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	139/524 (27%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	103/377 (27%)
CG10486	NP_647998.2	2A0119	104..612	CDD:273328	139/524 (27%)
CG10486	NP_647998.2	MFS	231..602	CDD:119392	105/383 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471407
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.960