DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and CG5592

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_647996.1	Gene:	CG5592 / 38662	FlyBaseID:	FBgn0035645	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	543	Identity:	158/543 - (29%)
Similarity:	244/543 - (44%)	Gaps:	53/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVP-DHWCYHEQLENRSYAEIAAIY 68
            ::..|:..||...:|..||.......|:.:..||.|..:..:| :|||...:||....:|.....
  Fly     9 YENFLLFIGDFGPFQKRLLFWMMPAAFLFAFTYFGQIFMILLPKNHWCRVRELEGLPESEQKNRG 73

  Fly    69 APFKRPSCTRLASINMDGS-------------------NATASSEPCNR-WIY-HYDHGFISMNA 112
            .|.|:           |||                   |.|.|..|||. ||| ..:..:.|:..
  Fly    74 IPKKQ-----------DGSFENCFMYNVPYDSNATNDANQTRSPIPCNNGWIYDRKEVPYESIAT 127

  Fly   113 DLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLT 177
            :.|||||..........::|||.:.|.|.||.:.|..||:.|:.|||.|..:|...::..:....
  Fly   128 EYNWVCDKRDFGTYSVVVYFVGCIVGCLCFGFITDHSGRLPALFLANSCSMIGGCVSVVCKDFPC 192

  Fly   178 FSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFM 242
            |:|||||:||:.......::||.||.|....|::..||.:..|:.||.....|....:.:||.:.
  Fly   193 FAASRFVAGLSMNYCFVPIYILTLENVGIKYRTLVGNLALTFFFTLGACLLPWLAYVISNWRHYA 257

  Fly   243 VWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKES 307
            :..|||.:.:.....|..||..||::....|.....::..||.|.:.:||..:...|:..:.|
  Fly   258 MVVALPIVFMILTSLLAPESPSWLMSVGKVDRCIEVMKEAAKANGKIISEEVWSEMRECYELK-- 320

  Fly   308 EARSQMSMQKQARLIDSFK-LPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFAL 371
            .|..|:.  ||...:|.|| .|||.:..|.: |.:..|.|.|:...|.||.|....|:.|||.:|
  Fly   321 FANEQLG--KQYTSLDLFKTFPRLVVLTILI-VTWMTVALAYDAHVRVVEILDTDIFITFSLSSL 382

  Fly   372 TLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATT----GILLAFWTQHSATVMVCLLLMCRFG 432
            ...|:||....:....|||    ..|:|..|:.|.:    |||...|...:|.:      ..||.
  Fly   383 VEIPAGIVPMLLLDRIGRK----PMMSAVMLLCAASSLFVGILKGHWNASTAAI------AARFF 437

  Fly   433 ISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSA 497
            .::......|.::|::||.:|..|||:|::.....:.:||.:|....|:|.....|..::.::.|
  Fly   438 ATMAYNVGQQWASEILPTVLRGQGLAIINIMGQMGALLSPLVLSTHRYYRPLPMFIITLVSVIGA 502

  Fly   498 WICLLLSETRNKKLPLTLAEGEE 520
            .|.|.|.||:...:|.||.|.|:
  Fly   503 LIILFLPETKGATMPQTLDEAEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	153/527 (29%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	113/378 (30%)
CG5592	NP_647996.1	2A0119	17..519	CDD:273328	153/527 (29%)
CG5592	NP_647996.1	MFS	141..509	CDD:119392	113/382 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.960