DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a12

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_038941497.1	Gene:	Slc22a12 / 365398	RGDID:	621628	Length:	578	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	144/619 - (23%)
Similarity:	248/619 - (40%)	Gaps:	117/619 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYM-LLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLEN-RSYAEIA 65
            |.|.|:|.:.|...|:|.: .:||...::::.::: ..:|....||.|.|:...|:| .|.|.|.
  Rat     1 MAFPELLDRVGGRGRFQLLQAVALVTPILWVTTQN-MLENFSAAVPHHRCWVPLLDNSTSQASIP 64

  Fly    66 AIY------------APFKRP-SCTR-------LASINMDGSN-ATASSEPC-NRWIYHYDHGFI 108
            ..:            .|.:|| .|.|       |...|...:| :.|.:||| :.|:  |||...
  Rat    65 GDFGRDVLLAVSIPPGPDQRPHQCLRFRQPQWQLIESNTTATNWSDADTEPCEDGWV--YDHSTF 127

  Fly   109 SMNADLNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAV----VLANCCGFLGDS 167
            .......|  |||......:.||:|..|.:.|..:.|...||.||.:.:    :|.:..|.:...
  Rat   128 RSTIVTTWDLVCDSQALRPMAQSIFLAGILVGAAVCGHASDRFGRRRVLTWSYLLVSVSGTIAAL 192

  Fly   168 ATIF-AETLLTFSASRFVSGLAAEANSYLMF--------------------ILVLEYVSP----- 206
            ...| ...|..|..:..|:|:.....|..||                    :.|:|:.|.
  Rat   193 MPTFPLYCLFRFLVASAVAGVMMNTASLCMFPVVLGREGYMQDPELTPSLLLAVMEWTSAQAGPL 257

  Fly   207 --TMRSVGLN----LTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQW 265
              |:.::|.:    ||..|.||            :.|||...:..:.|..|...:.:.:.|||:|
  Rat   258 MMTLNALGFSFGQVLTGSVAYG------------VRSWRMLQLAVSAPFFLFFVYSWWLPESARW 310

  Fly   266 LVTRQDFDGAELRLRRVAKFNRRDVSEAD---YELFRQHCKTKESEARSQMSMQKQARLIDSFKL 327
            |:|....|.:...|:|||..|||. :|||   .|:.|...:.:.:      ..|..|||......
  Rat   311 LITVGRLDQSLRELQRVAAVNRRK-AEADTLTVEVLRSAMQEEPN------GNQAGARLGTLLHT 368

  Fly   328 PRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFT 392
            |.||||.....:.:......:..::.:::.|..:.|::.:|..:...|..:....:....||:..
  Rat   369 PGLRLRTFISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDLPVKMGSLLLLSRLGRRLC 433

  Fly   393 SVVSMTATG-------LMTATTGILLAFWTQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPT 450
            ...|:...|       |:....|||.:         .:.:|.:...|.:.|..:.  .|:||.||
  Rat   434 QASSLVLPGLCILANILVPREMGILRS---------SLAVLGLGSLGAAFTCVTI--FSSELFPT 487

  Fly   451 CVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTL 515
            .:|.:.:.:..|.|...:.:.|.:..|..|......::..::.::|....|||.||:|..||.|:
  Rat   488 VIRMTAVGLGQVAARGGAMLGPLVRLLGVYGSWLPLLVYGVVPVLSGLAALLLPETKNLPLPDTI 552

  Fly   516 AEGEEFGKGERMFDFMRSFKKADQHDLSADTIEK 549
            .:.::           :|.||. .||::..::.|
  Rat   553 QDIQK-----------QSVKKV-THDIAGGSVLK 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	133/572 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	90/419 (21%)
Slc22a12	XP_038941497.1	MFS_OAT	109..541	CDD:340932	104/463 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950