DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	127/581 - (21%)
Similarity:	243/581 - (41%)	Gaps:	83/581 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FDEILVKCGDSHRYQYMLLALYGL-----LMFIVSRHYFAQNVIGFVPDHWCYH--------EQL 56
            |..:|...|:...:|:.|:||..:     ..|::|.|:.......:....|...        |||
  Rat    51 FASVLGAIGEFGTFQWRLVALTFIPSILSTFFLLSHHFLLTAQRPYCNTSWILQVGPNLTEDEQL 115

  Fly    57 E-------NRSYAEIAAIYAPFKRPSCTRLASINMDGSNATASSEPCNR-WIYHYDHGFISMNAD 113
            .       |.|:. ...:|.|..    ..|.||...|.|.|   |.|.. |||.:.| ..|:..:
  Rat   116 NLTVPRAPNGSFL-TCLMYIPVP----WDLDSIVHFGLNYT---ETCKHGWIYPFAH-TRSLTNE 171

  Fly   114 LNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTF 178
            .:.||.:......||::|..|.:.|:||||.|.|::||...::|:.....:....|.|..:...:
  Rat   172 FDLVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFGTAFVNSFYQY 236

  Fly   179 SASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMV 243
            ...||....|:...:.....||:|::....|:..:.|..| |:.:|:|..:.....:..||...:
  Rat   237 LFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAIILQHC-FFTIGVILLTGFAYKINHWRLLFL 300

  Fly   244 WTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESE 308
            ...:|...:....:::|||.:||:.:...:.|:..|...|:.|:               ||....
  Rat   301 LGGVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVLCYAAEVNK---------------KTIPLN 350

  Fly   309 ARSQMSM---QKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFA 370
            ..:::.:   :.:|.::|.:....|...::.:..|:..|:....|:|..::...:..:.:..:..
  Rat   351 LLNELQLPGKKAKASILDFYTNQHLFKVVLAMGCVWFTVSYVSLTLSLKMKDFGLDIYFIQVVPC 415

  Fly   371 LTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGISV 435
            :|..|:.:....:.::||||:    |:..|..:...|.:.|.|..:...:..:.:|::..|.::.
  Rat   416 ITAVPARLCCILLLEYFGRKW----SLNLTLSLVTFTCLSLLFVPEELKSTTILMLVLGEFSMAG 476

  Fly   436 TTGSTMQISTELMPTCVRSSGLAVIHV--TAAALSFISPF---ILHLDTYFRAASSIITCILLLV 495
            |.......:.||:||.:||:||.::.:  ||.|:|.::.|   ...|..:|    ..:.|||.|
  Rat   477 TVSIFFIYTAELLPTILRSTGLGMVSIAWTAGAISSLAIFKQTKTQLPIFF----CCLCCILAL- 536

  Fly   496 SAWICL--LLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIEKLMGDK 554
                |.  |:.||.|:    .|.:..|:...:.:          :..|.|.|:.:.||.::
  Rat   537 ----CFSSLVPETGNQ----PLRDSIEYCSRDSL----------EHKDKSKDSSKVLMAEE 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	118/531 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	81/383 (21%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	89/403 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100