DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	577	Identity:	130/577 - (22%)
Similarity:	240/577 - (41%)	Gaps:	67/577 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVI--GFVPDH-------------WCYH 53
            |:||::...|:...:|.::..|  |...|:...:...:|:  ...|:|             |..|
Mouse     3 DYDEVIAFLGEWGPFQRLIFFL--LSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNH 65

  Fly    54 E-QLENRSYAEIAAIYAPFKRPSCT--RLASI----------NMDGSNATASSEPC-NRWIYHYD 104
            . .||.:...::.        .||.  |||:|          ..|........|.| :.|.|..|
Mouse    66 SIPLETKDGRQVP--------QSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKD 122

  Fly   105 HGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDS-A 168
            ....::..:.|.||:|.:|..:..||||||.:||:.:.|.|.||.|| |.|:.|......|.| .
Mouse   123 IFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGR-KKVLFATMAVQTGFSFV 186

  Fly   169 TIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGV 233
            .||:.....|:....:.|:...:|..:.|||..|.:|.::|.:...|.:|.|:.:|.:.......
Mouse   187 QIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAY 251

  Fly   234 WLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELF 298
            ::..||..::...||.|.....::.|.||.:||::::.|..||..:::.||.|........::
Mouse   252 FIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFD-- 314

  Fly   299 RQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPF 363
                 ..|.:..:.:..|| ..::|.|:...:....:...:::.:.::.|..:|.||..|....:
Mouse   315 -----PLELQELNSLKQQK-VIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVY 373

  Fly   364 VMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWT--QHSATVMVCLL 426
            :...|..|...|:......:.:...|::      ...|::....|:||....  :....|.:.|:
Mouse   374 LNCFLSGLIEVPAYFTAWLLLRTLPRRY------IIAGVLFWGGGVLLLIQVVPEDYNFVSIGLV 432

  Fly   427 LMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCI 491
            ::.:|||:.........:.||.||.||:..:.:..:.:...|.|:|:.::|..|.|....|:...
Mouse   433 MLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGS 497

  Fly   492 LLLVSAWICLLLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIE 548
            |.::...|.|...|:....||..|.:.::          :|.|:...:..:|.|..|
Mouse   498 LTVLIGIITLFFPESFGVTLPENLEQMQK----------VRGFRCGKKSTVSVDREE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	121/532 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	89/376 (24%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	120/531 (23%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	94/401 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843855
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950