DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	119/563 - (21%)
Similarity:	244/563 - (43%)	Gaps:	31/563 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            |.|:::|.:.|...|:|.:.:.:....:.:::.|...||....:|.|.|......|.|.......
  Rat     1 MAFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRPPANANLSKDGGLEA 65

  Fly    68 YAPFKR----PSCTRLAS-------INMDGSNATASSEPC-NRWIYHYDHGFISMNADLNWVCDD 120
            :.|..:    .||.|..|       .|...:|.|..:||| :.|:|.......::..:.|.||..
  Rat    66 WLPLDKQGQPESCLRFTSPQWGPPFYNGTEANGTRVTEPCIDGWVYDNSTFPSTIVTEWNLVCSH 130

  Fly   121 AYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFVS 185
            ....::.|||:.||.:.|.::||.|.||:||.|.::|......:..:...:|.....:...|.:|
  Rat   131 RAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAYAPNYTVYCVFRLLS 195

  Fly   186 GLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQL 250
            |::..:.:.....|.:|:: |......:...:...|.||....:.....:..||...:..::|..
  Rat   196 GMSLASIAINCMTLNVEWM-PIHTRAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFF 259

  Fly   251 LVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFN--RRDVSEADYELFRQHCKTKESEARSQM 313
            :...:.:...|||:|..:....|.....|:|||:.|  :.:.::...|:.|       :..:.::
  Rat   260 IAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLR-------TSLQKEL 317

  Fly   314 SMQK-QARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPPSG 377
            ::.| ||..::..:.|.||...:.:::::...:..|..:..:::|..:|.:::..:|.....|:.
  Rat   318 TLSKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIFGAVDLPAK 382

  Fly   378 IFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGISVTTGSTMQ 442
            .....|....||:...:.|:...|:.....||:     ..|.|::...|.:...|...::.:.:.
  Rat   383 FVCFLVINSMGRRPAQMASLLLAGICILVNGII-----PKSHTIIRTSLAVLGKGCLASSFNCIF 442

  Fly   443 IST-ELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSET 506
            :.| ||.||.:|.:||.:....|...|.:||.:.....::.:....|...:.:|::.:..||.||
  Rat   443 LYTGELYPTVIRQTGLGMGSTMARVGSIVSPLVSMTAEFYPSMPLFIFGAVPVVASAVTALLPET 507

  Fly   507 RNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIEK 549
            ..:.||.|:.:.:...:|::  :..:..::.....|.|.|.||
  Rat   508 LGQPLPDTVQDLKSRSRGKQ--NQQQQEQQKQMMPLQASTQEK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	109/516 (21%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	75/377 (20%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	109/516 (21%)
		MFS	135..505	CDD:119392	77/382 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347404
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950