DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a29

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_766364.1	Gene:	Slc22a29 / 236293	MGIID:	3605624	Length:	551	Species:	Mus musculus

Alignment Length:	571	Identity:	138/571 - (24%)
Similarity:	252/571 - (44%)	Gaps:	77/571 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLEN--------- 58
            |.|.|:|.:.|...|:|.:.:....||..||..|...:|....:|:|.|:...|:|
Mouse     1 MSFQELLNQVGSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRCWVPILDNDTASDNGSR 65

  Fly    59 -RSYAEIAAIYAP----FKRPSCTRLAS-----INMDGSNATAS---SEPC-NRWIYHYDHGFIS 109
             .|..::..|..|    .:...|.|.|.     ::::|:.:..|   :||| :.|:|...:...:
Mouse    66 ILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTFSNVSEPDTEPCVDGWVYDRSNFLST 130

  Fly   110 MNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGF-LGDSATIFAE 173
            :..:.:.||:......|.:..|.:|...|.::.|.|.||.|| |.::......| :.::...||.
Mouse   131 IVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGR-KFILTCALLQFAITETCVAFAP 194

  Fly   174 TLLTFSASRFVSGLAAEANSYLMFILVLEYVSP-------TMRSVGLNLTMCVFYGLGMICASWQ 231
            :...:.:.||::|::.|..|....:|:||:.||       .:.|...|:...:..||..:
Mouse   195 SFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFL----- 254

  Fly   232 GVWLGSWRSFMVWTALPQLLVTG--FYFLI-----QESAQWLVTRQDFDGAELRLRRVAKFN-RR 288
                     |.:|..| ||.::.  |:|||     .|||:||:...........||:||..| .:
Mouse   255 ---------FRIWHHL-QLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMK 309

  Fly   289 DVSEADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSR 353
            :..:...|:.|...|.:...|:::.|::      |.|....||.|:..::.:....|:....::.
Mouse   310 NSGDLTMEIVRTSMKAELEAAKTKPSLR------DLFHTSILRKRICVLSFIRLFFTVSIIGLAV 368

  Fly   354 NVEGLSISPFV---MFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLA-FW 414
            :::.||.:..:   :.|..|:.:...|.|   |..|.||:.|.:|.|:..|:.     |::| |.
Mouse   369 HLQHLSSNIILLQFLISALAILVSVIGPF---VLNHIGRRITYLVLMSLRGIF-----IMIAVFV 425

  Fly   415 TQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDT 479
            .|...|:.:.:..:.....|:..|.:...:.||:||.:|::.|.||.....:..|:||..:.:.|
Mouse   426 PQEMQTLRIIMATLAGGISSLCVGVSHLHTNELLPTTLRATALGVIGFFGNSGLFLSPLFMLVAT 490

  Fly   480 YFRAASSIITCILLLVSAWICLLLSETRNKKLPLTL----AEGEEFGKGER 526
            |:.....|......:.:|:...||.||:|:.||.:.    .:.:|..||:|
Mouse   491 YYANLPWIFYGGFSIFNAFTVFLLPETKNQPLPDSTHDVGNDWKESRKGKR 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	130/543 (24%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	93/393 (24%)
Slc22a29	NP_766364.1	MFS_OAT	109..515	CDD:340932	103/435 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940