DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and Slc22a26

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_017173677.1	Gene:	Slc22a26 / 236149	MGIID:	2385316	Length:	553	Species:	Mus musculus

Alignment Length:	589	Identity:	152/589 - (25%)
Similarity:	237/589 - (40%)	Gaps:	129/589 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLEN--------- 58
            |.|.::|...|...|:|.:.:|...:...|...|...:|.......|.|:...::|
Mouse     1 MAFQDLLNLVGSHGRFQILQMAFLLICNVITMPHVILENFTAANLGHRCWVHIIDNDTNSNNNSG 65

  Fly    59 -RSYAEIAAIYAPFK---RP-SCTR-------LASINMDGSNAT-ASSEPC-NRWIYHYDHGFIS 109
             .|..::..|..|..   || .|.|       |...|...||.| ..:||| :.|:|. ...|:|
Mouse    66 ILSQDDLLRISIPLDSNLRPEKCRRFVQPQWHLLQFNGSFSNMTEPDTEPCMDGWVYD-QRTFLS 129

  Fly   110 MN-ADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGR--------IKAVVLANCCGFLG 165
            .. .:.|.||.......|.:.:|.:|.:.|..:.|.|.|:.||        ::..:...|
Mouse   130 TTVTEWNLVCGSQELNSVAKFIFLIGVLAGHFVGGHLSDKFGRKLLFRCALLQMAITGTC----- 189

  Fly   166 DSATIFAETLLTFSASRFVSGLA---AEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMIC 227
               |..|.|...:...||::||.   ...||.|   |:||:.||..:::...|:|...:..|:|.
Mouse   190 ---TALAPTFFIYCLLRFLTGLCIIPINTNSVL---LMLEWTSPKTQALVTTLSMSSHHFGGLIL 248

  Fly   228 ASWQGVWLGSWRSFMVWTALPQLLVTGFYFL--------IQESAQWLVTRQDFDGAELRLRRVAK 284
            |       |...:|..|..| ||.::...|:        :.|||:||:.......|...||:||.
Mouse   249 A-------GLAFAFQNWHHL-QLAISVPIFVLLIPTSRWLTESARWLIVTNKPQKALQELRKVAS 305

  Fly   285 FNRRDVSE--ADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLC 347
            .|....||  ...|:.|...|.:.:..|::.|::      |.|.:|.||.||         ..||
Mouse   306 KNGIKNSEDVLTMEVVRTIMKDEIAIPRTKPSLR------DLFHMPNLRKRL---------CLLC 355

  Fly   348 YNTMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLA 412
            .      :..|.|||.|..::....| ...:|.||       ..||..|:.||.|    .|.||.
Mouse   356 L------LRFLQISPTVGINMNLQHL-KGNVFLTQ-------SLTSAFSIPATAL----GGFLLN 402

  Fly   413 FWTQHSATVMVCLLLMCRFG--------------------ISVTTGSTMQI-------STELMPT 450
            :..:..:.::.|||    ||                    |::..||:..|       |:|||||
Mouse   403 YIGRRISQLLPCLL----FGIFLLSIVSVPQEMQTLLVVLITLAGGSSAMIYNSNVLYSSELMPT 463

  Fly   451 CVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSETRNKKLPLTL 515
            .:|::.|.||.:.....:.:||.|:.|..|..:...||..:|.::...:.|:|.||:|:.||.::
Mouse   464 VIRATALGVIGICGGVGAALSPLIMILTLYSASLPWIIYGVLSILGGLLPLILPETKNQPLPDSI 528

  Fly   516 AEGE 519
            .:.|
Mouse   529 QDVE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	148/572 (26%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	109/421 (26%)
Slc22a26	XP_017173677.1	MFS	109..506	CDD:391944	119/453 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030