DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and Slc22a3

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_035525.1	Gene:	Slc22a3 / 20519	MGIID:	1333817	Length:	551	Species:	Mus musculus

Alignment Length:	572	Identity:	140/572 - (24%)
Similarity:	243/572 - (42%)	Gaps:	92/572 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FDEILVKCGDSHRYQ---YMLLALYGLLMFIVSRHYFAQNVIGFV-----PD-HWCYHEQLENRS 60
            ||:.|.|.|:..|:|   ::||.|.|:.        ||...:|.|     || :||...:.  .:
Mouse     4 FDQALRKAGEFGRFQRRVFLLLCLTGVT--------FAFLFVGVVFLGSQPDYYWCRGPRA--TA 58

  Fly    61 YAEIAA-------------IYAPFKRPS---CTRLASINMDGSNATASSEPC-------NR---- 98
            .||..|             ::.|.:|..   |.|..   ::.:| |:|...|       ||
Mouse    59 LAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYL---LEATN-TSSELSCDPLTAFPNRSAPL 119

  Fly    99 ------WIYHYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVL 157
                  |.|...|..|....||  ||.:|:...:.|::..:|.:.|....|...||.||: .:.|
Mouse   120 VSCSGDWRYVETHSTIVSQFDL--VCSNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRL-IIYL 181

  Fly   158 ANCCGFLGDSATI--FAETLLTFSASRFVSGLAAEANSYLMFILVLEYV-SPTMRSVGLNLTMCV 219
            .:|.| :|.:..:  ||.....|...||:.|:..:......|::|.|.| |...|.||:.:.|
Mouse   182 ISCFG-VGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQM-- 243

  Fly   220 FYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAK 284
            |:.||:|.......:..||:...:..:||..|...:|:::.||.:||:||:..:.|...||||||
Mouse   244 FFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAK 308

  Fly   285 FNRRDVSEADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYN 349
            .|.:.:|....|:      |...|..|..|      .:|..:.|::|...:.:...:....:.|.
Mouse   309 CNGKHLSSNYSEI------TVTDEEVSNPS------CLDLVRTPQMRKCTLILMFAWFTSAVVYQ 361

  Fly   350 TMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFW 414
            .:...:..:..:.::.|.:..|...|..:......:..||:    :...|:.::...:.::.||.
Mouse   362 GLVMRLGLIGGNLYIDFFISGLVELPGALLILLTIERLGRR----LPFAASNIVAGVSCLVTAFL 422

  Fly   415 TQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDT 479
            .:....:...:..:.|.||::.......:::||.||.:|:.|:::..........|:||:|
Mouse   423 PEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLL---- 483

  Fly   480 YFRAAS------SIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFGKGE 525
             ||.|:      .||..||..|...:.:||.||:...||.|:.:.|:.|..:
Mouse   484 -FRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQ 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	133/551 (24%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	89/382 (23%)
Slc22a3	NP_035525.1	2A0119	12..523	CDD:273328	133/551 (24%)
Slc22a3	NP_035525.1	MFS	145..513	CDD:119392	92/392 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844070
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950