DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	559	Identity:	125/559 - (22%)
Similarity:	227/559 - (40%)	Gaps:	70/559 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 DEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIA--AIY 68
            |::|...|:...:|.....|..|:...::..|.....:||.|||.|     .:...||::  ..:
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHC-----RSPGVAELSQRCGW 64

  Fly    69 APFKR-----------------PSCTR---------------LASINMDGSNATASSEPCNR-WI 100
            :|.:.                 ..|.:               |:|:..:.|:...|  ||.. |:
Mouse    65 SPAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLS--PCEHGWV 127

  Fly   101 YHYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLG 165
              ||....|:..:.|.||.||:|..:.||...:|...|:|:.|.:.||.||...:::......|.
Mouse   128 --YDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLS 190

  Fly   166 DSATIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFY----GLGMI 226
            ...|..|....:....|.:.|:.::.:....:.|:.|:|..     |...|..:.|    .:|::
Mouse   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGS-----GYRRTTAILYQVAFTVGLV 250

  Fly   227 CASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVS 291
            ..:.....:..||...:..:||..|...:|:.:.||.:||::::....|...:.::|:.||: |.
Mouse   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRK-VP 314

  Fly   292 EADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLR-LIYVTVVFSIVTLCYNTMSRNV 355
            .||.::.   |..:::..|...|      ..|.|:.|.||.. ||.:.:.||...| |..:..:|
Mouse   315 PADLKMM---CLEEDASERRSPS------FADLFRTPSLRKHTLILMYLWFSCAVL-YQGLIMHV 369

  Fly   356 EGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSAT 420
            .....:.::.|...:|...|:...........||    :..:.|:.|:.....:|:.|.......
Mouse   370 GATGANLYLDFFYSSLVEFPAAFIILVTIDRIGR----IYPIAASNLVAGAACLLMIFIPHELHW 430

  Fly   421 VMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPF-ILHLDTYFRAA 484
            :.|.|..:.|.|.::.......::.||.||.:|:.|:.|...........:|| :..|...::|.
Mouse   431 LNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQAL 495

  Fly   485 SSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFGK 523
            ..|:..:|.|.:..:.|||.||:...||.|:.|.|..|:
Mouse   496 PLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGR 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	119/541 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	81/379 (21%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	119/541 (22%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	93/411 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843897
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950