Protein Alignment CG14856 and Slc22a1

DIOPT Version :10

• Sequence 1: NP_650391.1
• Gene: CG14856 / 41790
• FlyBaseID: FBgn0038261
• Length: 557
• Species: Drosophila melanogaster
• Sequence 2: NP_033228.2
• Gene: Slc22a1 / 20517
• MGIID: 108111
• Length: 556
• Species: Mus musculus
• Alignment Length: 559
• Identity: 125/559 - (22%)
• Similarity: 227/559 - (40%)
• Gaps: 70/559 - (12%)

  Fly     6 DEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIA--AIY 68
            |::|...|:...:|.....|..|:...::..|.....:||.|||.|     .:...||::  ..:
Mouse     5 DDVLEHVGEFGWFQKQAFLLLCLISASLAPIYVGIVFLGFTPDHHC-----RSPGVAELSQRCGW 64

  Fly    69 APFKR-----------------PSCTR---------------LASINMDGSNATASSEPCNR-WI 100
            :|.:.                 ..|.:               |:|:..:.|:...|  ||.. |:
Mouse    65 SPAEELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLS--PCEHGWV 127

  Fly   101 YHYDHGFISMNADLNWVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLG 165
              ||....|:..:.|.||.||:|..:.||...:|...|:|:.|.:.||.||...:::......|.
Mouse   128 --YDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSLS 190

  Fly   166 DSATIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFY----GLGMI 226
            ...|..|....:....|.:.|:.::.:....:.|:.|:|..     |...|..:.|    .:|::
Mouse   191 GVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGS-----GYRRTTAILYQVAFTVGLV 250

  Fly   227 CASWQGVWLGSWRSFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVS 291
            ..:.....:..||...:..:||..|...:|:.:.||.:||::::....|...:.::|:.||: |.
Mouse   251 GLAGVAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIMEQIAQKNRK-VP 314

  Fly   292 EADYELFRQHCKTKESEARSQMSMQKQARLIDSFKLPRLRLR-LIYVTVVFSIVTLCYNTMSRNV 355
            .||.::.   |..:::..|...|      ..|.|:.|.||.. ||.:.:.||...| |..:..:|
Mouse   315 PADLKMM---CLEEDASERRSPS------FADLFRTPSLRKHTLILMYLWFSCAVL-YQGLIMHV 369

  Fly   356 EGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSAT 420
            .....:.::.|...:|...|:...........||    :..:.|:.|:.....:|:.|.......
Mouse   370 GATGANLYLDFFYSSLVEFPAAFIILVTIDRIGR----IYPIAASNLVAGAACLLMIFIPHELHW 430

  Fly   421 VMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPF-ILHLDTYFRAA 484
            :.|.|..:.|.|.::.......::.||.||.:|:.|:.|...........:|| :..|...::|.
Mouse   431 LNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQAL 495

  Fly   485 SSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFGK 523
            ..|:..:|.|.:..:.|||.||:...||.|:.|.|..|:
Mouse   496 PLILFGVLGLSAGAVTLLLPETKGVALPETIEEAENLGR 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	119/541 (22%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	119/541 (22%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15245	284..288		2/3 (67%)