DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	565	Identity:	134/565 - (23%)
Similarity:	222/565 - (39%)	Gaps:	74/565 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQLENRSYAEIAAI 67
            |.|.|||.:.|....:||:.:.|..|.:..::.|...|......|||.|  ....|.|.......
Mouse     1 MTFSEILDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATTPDHHC--RPPPNASLEPWVLP 63

  Fly    68 YAPFKRP-SCTRL-----ASINMDGSNATASSEPC-NRWIYHYDHGFISMNADLNWVCDDAYKAR 125
            ..|..:| .|.|.     ||:..|...||   ||| :.|||:.....|....||  ||.......
Mouse    64 LGPNGKPEKCLRFVHLPNASLPNDTQGAT---EPCLDGWIYNSTRDTIVTEWDL--VCGSNKLKE 123

  Fly   126 VGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSASRFVSGLAAE 190
            :.||:|..|.:.|..:||.|.||.||...:..:........|:..|:.:|..:...||:.|.:..
Mouse   124 MAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSIS 188

  Fly   191 ANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWTALPQLLVTGF 255
            ..|....||.:|:|..:.|::. :.|:...|.:|..........:..||    |.   ||.|:..
Mouse   189 GISLSTIILNVEWVPTSTRAIS-STTIGYCYTIGQFILPGLAYAVPQWR----WL---QLSVSAA 245

  Fly   256 YFL-------IQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEARS-- 311
            :|:       :.||.:|||....|..|...|:|||.||.               |.:|.|..:
Mouse   246 FFIFSLLSWWVPESIRWLVLSGKFSKALKTLQRVATFNG---------------KKEEGEKLTVE 295

  Fly   312 --QMSMQKQAR-------LIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFS 367
              :.::||...       |.|.|::..||.....:::.:......|.:::..||...::.:::..
Mouse   296 ELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEFGVNIYILQI 360

  Fly   368 LFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFG 432
            :|.....|:.........:.||:.|.       |.:....|:.:......|:.:.:....:..||
Mouse   361 IFGGVDIPAKFITILSISYLGRRITQ-------GFLLILAGVAILALIFVSSEMQLLRTALAVFG 418

  Fly   433 ISVTTGS---TMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLL 494
            ....:||   ....::||.||.:|.:|:.:.::.|...|.|:|.:...........::|...:.|
Mouse   419 KGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPFIPNVIFGTMTL 483

  Fly   495 VSAWICLLLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQ 539
            :.......|.||.|:.||.|:         |.:.|:.:..||..|
Mouse   484 LGGSAAFFLLETLNRPLPETI---------EDIQDWYQQTKKTKQ 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	123/528 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	83/394 (21%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	123/528 (23%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844019
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.950