DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and C06H5.6

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_507509.3	Gene:	C06H5.6 / 180170	WormBaseID:	WBGene00007394	Length:	556	Species:	Caenorhabditis elegans

Alignment Length:	569	Identity:	135/569 - (23%)
Similarity:	235/569 - (41%)	Gaps:	65/569 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQ----------YMLLALYGLLM-FIVSRHYFAQNVIGFVPDHWCYHEQL 56
            :|.|::|...|...|||          :||.||..::| ||.....|..:    :||    .|.:
Worm    25 LDADKVLTAFGKYGRYQMLAYVITTSVHMLFALNMMIMPFITKSVEFLCD----LPD----PESI 81

  Fly    57 ENRSYAEIAAIYAPFKRPSC----TRLASINMDGSNATASSEPCNRWIYHY--DHGFISMNADLN 115
            :       :|.::|....||    |:|        |.|......|...|:|  |.. .::.:|.:
Worm    82 D-------SAHFSPLVGDSCHLQDTQL--------NITIDCLAVNGASYNYLADKK-STITSDFD 130

  Fly   116 WVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSA 180
            .||:....|....|:|.||.|..:.....|.|.:||....::........:.....|...|.|..
Worm   131 LVCEYQGMAEHATSIFLVGGMIVSPFVSQLSDILGRRPLFLIPLYISVAANLICAAAPNYLIFLL 195

  Fly   181 SRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASWQGVWLGSWRSFMVWT 245
            .||:||:|..:.|...|:|.:|.||...||:...||...:.| |.:.|....|:..:||......
Worm   196 FRFISGVATTSFSMTGFVLCMESVSLEFRSLIPVLTTISWVG-GYMLAGVFYVFFKNWRVLYFAA 259

  Fly   246 ALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKTKESEAR 310
            ::|.||...|::...||..||:|:|:....:..:.....||::.:|..|       |:..::...
Worm   260 SVPGLLTIPFFWFTPESLHWLMTKQNDRKIKKYINESVAFNKQTISLID-------CRNIQTVDN 317

  Fly   311 SQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSLFALTLPP 375
            :..:  .:.|...:...|::.:.::..:.:..:::..|..:|.....||......:.|..|...|
Worm   318 APAT--TKTRTFRALFYPKIFVHVVINSFILIVMSGTYWALSLYSTELSEDETTGYFLSGLVELP 380

  Fly   376 SGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGISVTTGST 440
            :|.....:...|.||..|..|:..|.:.     :|...:........:...|:.:...|:...|.
Worm   381 AGFLSVFLLIAFKRKTVSFYSLAFTAVF-----MLCTVYIPMQGNYKMIFPLLAKSTNSIVWASQ 440

  Fly   441 MQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAWICLLLSE 505
            ..:.:|..||.:|:....|:.......|..:|::..|....:.|.:|:..|:.:|:|::.||..|
Worm   441 PLLYSEATPTTIRNVFSGVVSFVGELGSIGAPYMNRLTAINQDAPAILISIMSIVAAFLVLLQPE 505

  Fly   506 TRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIEKLMGDK 554
            |:|||||..|   ::|..|    ...|.:||  |.||.|....:.:.:|
Worm   506 TKNKKLPEDL---DQFDAG----PLFRGWKK--QKDLEASEASEEVKEK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	121/517 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	82/373 (22%)
C06H5.6	NP_507509.3	MFS_SLC22	115..504	CDD:340875	90/404 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010