DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and Slc22a7

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_659105.2	Gene:	Slc22a7 / 108114	MGIID:	1859559	Length:	540	Species:	Mus musculus

Alignment Length:	564	Identity:	129/564 - (22%)
Similarity:	241/564 - (42%)	Gaps:	77/564 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWC---------YHEQLEN 58
            |.|:|:|.|.|....:|...|.|..|..|::..|:.....:..||.|.|         .|:.|..
Mouse     1 MGFEELLHKVGGFGPFQLRNLVLLALPRFLLPMHFLLPIFMAAVPAHHCALPDAPANLSHQDLWL 65

  Fly    59 RSY--AEIAAIYAPFKRPSCTRLA------SINMDGSNATASSE--------PCNR-WIYHYDHG 106
            :::  .|....::     ||.|.|      ::.: |:....|.|        ||:: |  .||..
Mouse    66 KTHLPRETDGSFS-----SCLRFAYPQALPNVTL-GTEVYNSGEPEGEPLTVPCSQGW--EYDRS 122

  Fly   107 FISMNADLNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLAN----CCGFLG 165
            ..|......|  ||......:|..:.||:|.:.|.:::|.|.||.||.:.:::|.    ..|.:.
Mouse   123 EFSSTIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVYGYLSDRFGRRRLLLVAYVSTLALGLMS 187

  Fly   166 DSATIFAETLLTFSASRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVFYGLGMICASW 230
            .::..:    :.|..:|.::|.|....:.::..|.||::....|:|. .:....|:..|::..:.
Mouse   188 AASVNY----IMFVTTRMLTGSALAGFTIIVLPLELEWLDVEHRTVA-GVISTTFWTGGVLLLTL 247

  Fly   231 QGVWLGSWRSFMVWTALPQLLVTGFYFL--IQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEA 293
            .|..:.|||..::...||  .|.|...:  :.|||:||:|:...:.|:..|...||.|.|.:||
Mouse   248 VGYLIRSWRWLLLAATLP--CVPGIISIWWVPESARWLLTQGRVEEAKKYLSICAKLNGRPISE- 309

  Fly   294 DYELFRQHCKTKESEARSQMSMQK---------QARLIDSFKLPRLRLRLIYVTVVFSIVTLCYN 349
                          ::.||.::.|         :...:|.|:..:||...:...:::..|...|.
Mouse   310 --------------DSLSQEALNKVITMERVSQRPSYLDLFRTSQLRHVSLCCMMMWFGVNFSYY 360

  Fly   350 TMSRNVEGLSISPFVMFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFW 414
            .::.:..||.::.:....||.....||.|....:.:..||:.|....:.||.|   |.||.|...
Mouse   361 GLTLDASGLGLTVYQTQLLFGAVEVPSKITVFFLVRLVGRRLTEAGMLLATAL---TFGISLLVS 422

  Fly   415 TQHSATVMVCLLLMCRFGISVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDT 479
            :...:.:...:::...|..:..|.:.: .::||.||.:|.:|:....:.....:.::|.::.||.
Mouse   423 SDTKSWITALVVIGKAFSEAAFTTAYL-FTSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDG 486

  Fly   480 YFRAASSIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFGK 523
            .:.....:....:..::|...|||.||:..:||.|:.:.|..|:
Mouse   487 VWLLLPKLAYGGISFLAACTVLLLPETKKAQLPETIQDVERKGR 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	121/543 (22%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	84/388 (22%)
Slc22a7	NP_659105.2	2A0119	11..521	CDD:273328	121/543 (22%)
Slc22a7	NP_659105.2	MFS	146..511	CDD:119392	85/390 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57756
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950