DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14856 and slc22a8

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_002937554.2	Gene:	slc22a8 / 100490266	XenbaseID:	XB-GENE-22061134	Length:	556	Species:	Xenopus tropicalis

Alignment Length:	566	Identity:	132/566 - (23%)
Similarity:	233/566 - (41%)	Gaps:	53/566 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWC-------YHEQLENRS 60
            |.|.|:|.:.|...|:|...:.|....:.:::.|...||....:|||.|       .....:...
Frog     1 MSFAELLERTGGMGRFQITQVVLLCFPILLMASHNLLQNFSAAIPDHKCKANDTGYQSNSTDETG 65

  Fly    61 YAEIAAIYAPFKRPS-CTRLASI--NMDGSNAT--ASSE----PCN-RWIYHYDHGFISMNADLN 115
            |..::|......:|. |.....|  .|.|||:|  .|||    ||. .|.|..|....::..:.:
Frog    66 YERLSAPLDANGQPDRCLEYVEIQWRMVGSNSTWNNSSELATRPCTIGWEYSKDEFSSTIITEWD 130

  Fly   116 WVCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLLTFSA 180
            .||....:.::.||::..|.:.|.::.|.|.||.||...::.:.....:......|:...|::..
Frog   131 LVCGRKTRRQLAQSIYMGGVLVGAIILGGLSDRYGRRALLIWSYFQLAVSGVCAAFSPNYLSYCI 195

  Fly   181 SRFVSGLAAEANSYLMFILVLEYVSPTMRSVGLNLTMCVF-YGLGMICASWQGVWLGSWRSFMVW 244
            .||::|:|..........|::|:|...:|:|  ..|:..| |..|.:..:.....:..||...:.
Frog   196 FRFLTGMALSGIGLNTTALIVEWVPTRVRTV--TGTLAGFSYTAGQLLLAGLAYGMRDWRWLQLC 258

  Fly   245 TALPQLLVTGFYFL----IQESAQWLVTRQDFDGAELRLRRVAKFN--RRDVSEADYELFRQHCK 303
            .:||..:    |||    ..|||:|||.....:.|...:|:||..|  :.:..:...|..:....
Frog   259 VSLPFFI----YFLYAWWFPESARWLVLSGKPEKAVKEIRKVANLNGKKEEGEKITLESLKSEMI 319

  Fly   304 TKESEARSQMSMQKQARLIDSFKLPRLRLRLIYVTVVFSIVTLCYNTMSRNVEGLSISPFVMFSL 368
            .:.:.|:|..|      :||..:...:|.....:::|:...:..|..::.:::..::|.:::..:
Frog   320 KELASAKSSYS------VIDLVRTNTIRRISCALSLVWFSTSFAYYGLAMDLQKFNVSIYLIQVI 378

  Fly   369 FALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATVMVCLLLMCRFGI 433
            |.....|:.:.......:.|||||..:|:...|:..    |...|......||...|.:..:..:
Frog   379 FGAVDFPAKLVSATAMIYVGRKFTQFMSLILGGIAI----IANIFVPNELQTVRTSLAVFGKGCL 439

  Fly   434 SVTTGSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAASSIITCILLLVSAW 498
            :.:.......:|||.||.:|.|||.:....|.....::|.:..|...:.....:|.....::|..
Frog   440 AASFSCIFLYTTELYPTVIRQSGLGMCSTMARIGGIVAPLVKILGELYPFVPLLIYGGAPIISGL 504

  Fly   499 ICLLLSETRNKKLPLTLAEGE--------EFGKGERMFDFMRSFKK 536
            ....|.||.||.||.|:.|.|        |..|.|     |.|.|:
Frog   505 CVFFLPETVNKPLPDTIEEVEKGINAPKKEIEKNE-----MDSLKR 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	119/524 (23%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	80/380 (21%)
slc22a8	XP_002937554.2	MFS_SLC22A6_OAT1_like	105..510	CDD:341004	88/420 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100