DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14856 and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_650391.1	Gene:	CG14856 / 41790	FlyBaseID:	FBgn0038261	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	585	Identity:	146/585 - (24%)
Similarity:	254/585 - (43%)	Gaps:	75/585 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MDFDEILVKCGDSHRYQYMLLALYGLLMFIVSRHYFAQNVIGFVPDHWCYHEQL------ENRSY 61
            |.|:::|.:.....|:|.|:|.:..|..|.:..|:...|.|..:|.|.|....|      ||.|.
Zfish     1 MRFEDLLSELNGFGRFQKMVLCINFLGRFSLGCHFLLGNFIAAIPSHHCNISSLDVDGVFENLSQ 65

  Fly    62 AEIAAIYAP------------FKRPSCTRLASINMDGSNATASSEPCNRWIYHYDHG-FISMNAD 113
            .|...:..|            |..|....|  ||...|:.....|..|.|  |:|:. |||..|
Zfish    66 EERLTVGVPAQEDGTPASCHMFSHPQFQLL--INSSSSSDLPVVECQNGW--HFDNSTFISTLA- 125

  Fly   114 LNW--VCDDAYKARVGQSLFFVGSMCGTLLFGLLGDRIGRIKAVVLANCCGFLGDSATIFAETLL 176
            ..|  |||.....::..::||:|.|.|...||.|....||...::::...|......::.:.:|:
Zfish   126 TQWDLVCDKRALGKLTTTIFFLGVMFGAAAFGSLSAMFGRKPMLLVSYILGMGFGLCSVLSSSLV 190

  Fly   177 TFSASRFVSGLAAEANSYLMFILVLEYVSPTMRS-VGLNLTMCVFYG-LGMICASWQGVWLGSWR 239
            .|:..||.||.....:..:..:|.:|:||...|. ||:..::...:| :|....::   ::..||
Zfish   191 MFAVLRFFSGFTITGSVIISTVLNVEWVSIEHRKLVGVIDSLAWTFGFMGFPVIAY---FIRDWR 252

  Fly   240 SFMVWTALPQLLVTGFYFLIQESAQWLVTRQDFDGAELRLRRVAKFNRRDVSEADYELFRQHCKT 304
            ...|..:||.::....::.:.|||:||:.....|.|...|::.|..|.:
Zfish   253 WLTVAISLPNVISIITWWWVPESARWLIVNGKADKAHYYLKKCAAMNHK---------------- 301

  Fly   305 KESEAR------SQMSM----QKQARLIDSFKLPRLRLRLIYVTVV--FSIVTLCYNTMSRNVEG 357
            ||..||      |::.:    .::...:|..:.|::| ||..:|.:  ||:.|:.|. :|.|:.|
Zfish   302 KEVTARIKPEDLSKIIVTDRGSRKYSYLDLVRTPKMR-RLSLLTGITWFSVATVAYG-ISFNITG 364

  Fly   358 LSISPFV-MFSLFALTLPPSGIFQTQVQKHFGRKFTSVVSMTATGLMTATTGILLAFWTQHSATV 421
            ..::.:: .|...|:.:|........:.| |||..|...|:...|:     ..::..:.....||
Zfish   365 FGLNMYLTQFVYGAIEIPAKFCIYYLLDK-FGRHVTQAGSLLFVGI-----SFIINIFIPKEKTV 423

  Fly   422 MVCLLLMCRFGISVTT-GSTMQISTELMPTCVRSSGLAVIHVTAAALSFISPFILHLDTYFRAAS 485
            :..::.:...|.|.|: |:.:..::||.||.||.:|:......|.....::|.||..:..:...|
Zfish   424 IRTVIAVLGKGCSATSFGTVILYTSELYPTVVRQNGMGYTSFIARFGVSVAPLILLSNDVWSYFS 488

  Fly   486 SIITCILLLVSAWICLLLSETRNKKLPLTLAEGEEFGKGERMFDFMRSFKKADQHDLSADTIEKL 550
            .:|.|.|.|.:|::...|.||..|.||.|:.:.|...|.:.  ..:...:|.::    .|.:|||
Zfish   489 QVILCFLALSAAFVAYQLPETSGKCLPETIDDIEGIRKDKN--GLLLQDRKMEE----KDNMEKL 547

Fly 551 550
Zfish 548 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14856	NP_650391.1	2A0119	13..514	CDD:273328	135/537 (25%)
CG14856	NP_650391.1	MFS	129..503	CDD:119392	92/389 (24%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	135/536 (25%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	92/390 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588991
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284622at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950